Mouse Anti-Fer Recombinant Antibody (VS3-FY2609) (CAT#: VS3-FY2609)

• Host Species
• Mouse

• Type
• Mouse IgG

• Specificity
• FER tyrosine kinase of human, mouse and rat origins

• Species Reactivity
• Human, Mouse, Rat

• Applications
• WB, ICC, FC

• Conjugate
• Unconjugated, FITC

• MW
• The molecular weight of the target protein is approximately 94.6 kDa.

• Related Disease
• Cancer

• Clonality
• Monoclonal Antibody

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/2000
  Immunocytochemistry: 1/10-1/25
  Flow cytometry: 1/10-1/25

• Alternative Names
• FER Tyrosine Kinase; Fujinami Poultry Sarcoma/Feline Sarcoma-Related Protein Fer; Protein Phosphatase 1, Regulatory Subunit 74; Feline Encephalitis Virus-Related Kinase FER; Fer (Fps/Fes Related) Tyrosine Kinase; Phosphoprotein NCP94; Proto-Oncogene C-Fer; Tyrosine Kinase 3

• Gene ID
• 14158

• UniProt ID
• P70451

• Sequence Similarities
• Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.

• Cellular Localization
• Cytoplasm
  Cytoplasm, cytoskeleton
  Cell membrane; Peripheral membrane protein; Cytoplasmic side
  Cell projection
  Cell junction
  Membrane; Peripheral membrane protein; Cytoplasmic side
  Nucleus
  Cytoplasm, cell cortex

• Post Translation Modifications
• Autophosphorylated.
  Polyubiquitinated; this leads to proteasomal degradation.
  Ubiquitination at Lys610
  Modification sites at PhosphoSitePlus
  Glycosylation from GlyGen 1 site, 1 O-linked glycan (1 site)

• Protein Refseq
• XP_011541571.1; XP_011541572.1; XP_011541578.1; XP_016864719.1; XP_016864720.1

• Function
• Acts downstream of EGFR, KIT, PDGFRA and PDGFRB.
  Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation.
  May play a role in the regulation of the mitotic cell cycle.
  Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase.
  Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells.
  Plays a role in the regulation of mast cell degranulation.
  Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS).
  Plays a role in synapse organization, trafficking of synaptic vesicles, the generation of excitatory postsynaptic currents and neuron-neuron synaptic transmission.
  Plays a role in neuronal cell death after brain damage.

Secondary Antibody

• 2ND-040CQ
• Goat Anti-Mouse IgG (H&L) Antibody

Isotype Control

• MRO-A1591-YJ
• Mouse IgG Isotype control, Polyclonal

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