Mouse Anti-Fer Recombinant Antibody (VS3-FY2609)
CAT#: VS3-FY2609
The anti-Fer product is a recombinant mouse monoclonal antibody that binds to Fer. The calculated molecular weight of the antigen is 94.6 kDa. It exhibits cross-reactivity with human, mouse and rat. The antibody can be utilized for detection of Fer by Western Blot, Immunocytochemistry, Flow cytometry.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7641/45_B5_1_selected.jpg
Normal Tissue
Figure 2 IHC staining of human tonsil
Immunohistochemical staining of human tonsil shows moderate nuclear positivity in lymphoid cells outside reaction center.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7641/ihc_selected.jpg
Normal Tissue
Figure 3 IHC staining of human pancreas
Immunohistochemical staining of human pancreas shows strong cytoplasmic positivity in exocrine cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/22464/ihc_selected.jpg
Normal Tissue
Figure 4 Cerebral cortex
Glial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/22464/54455_B_9_5.jpg
Normal Tissue
Figure 5 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/22464/54455_A_9_3.jpg
Normal Tissue
Figure 6 Liver
Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/22464/54455_A_9_4.jpg
Normal Tissue
Figure 7 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/22464/54455_A_8_5.jpg
Normal Tissue
Figure 8 Testis
Cells in seminiferous ducts Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/22464/54455_A_4_6.jpg
Normal Tissue
Figure 9 Lymph node
Germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/22464/54455_A_7_8.jpg
RNA Expression
Figure 10 RNA cell line category: Cell line enriched (RPMI-8226)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000151422-FER
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Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- FER tyrosine kinase of human, mouse and rat origins
- Species Reactivity
- Human, Mouse, Rat
- Applications
- WB, ICC, FC
- Conjugate
- Unconjugated, FITC
- MW
- The molecular weight of the target protein is approximately 94.6 kDa.
- Related Disease
- Cancer
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/2000
Immunocytochemistry: 1/10-1/25
Flow cytometry: 1/10-1/25
Target
- Alternative Names
- FER Tyrosine Kinase; Fujinami Poultry Sarcoma/Feline Sarcoma-Related Protein Fer; Protein Phosphatase 1, Regulatory Subunit 74; Feline Encephalitis Virus-Related Kinase FER; Fer (Fps/Fes Related) Tyrosine Kinase; Phosphoprotein NCP94; Proto-Oncogene C-Fer; Tyrosine Kinase 3
- Gene ID
- 14158
- UniProt ID
- P70451
- Sequence Similarities
- Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.
- Cellular Localization
- Cytoplasm
Cytoplasm, cytoskeleton
Cell membrane; Peripheral membrane protein; Cytoplasmic side
Cell projection
Cell junction
Membrane; Peripheral membrane protein; Cytoplasmic side
Nucleus
Cytoplasm, cell cortex
- Post Translation Modifications
- Autophosphorylated.
Polyubiquitinated; this leads to proteasomal degradation.
Ubiquitination at Lys610
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- XP_011541571.1; XP_011541572.1; XP_011541578.1; XP_016864719.1; XP_016864720.1
- Function
- Acts downstream of EGFR, KIT, PDGFRA and PDGFRB.
Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation.
May play a role in the regulation of the mitotic cell cycle.
Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase.
Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells.
Plays a role in the regulation of mast cell degranulation.
Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS).
Plays a role in synapse organization, trafficking of synaptic vesicles, the generation of excitatory postsynaptic currents and neuron-neuron synaptic transmission.
Plays a role in neuronal cell death after brain damage.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "FER"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1989MZ | Recombinant Mouse Anti-Human FER Antibody (clone 3469D4b) | WB | Mouse antibody |
| ZG-0339J | Mouse Anti-FER Recombinant Antibody (ZG-0339J) | WB, IHC, IF, ELISA | Mouse IgG |
| VS3-XY700 | Mouse Anti-FER Recombinant Antibody (clone 5D2C4) | ELISA, WB, IHC, ICC | Mouse IgG1 |
| VS3-WK812 | Mouse Anti-FER Recombinant Antibody (VS3-WK812) | WB, ICC, FC | Mouse IgG2a, κ |
| VS7-HM940 | Mouse Anti-FER Recombinant Antibody (clone CBL278HM) | WB, IHC-p, IF, ICC, ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1283 | Hi-Affi™ Rabbit Anti-FER Recombinant Antibody (clone DS1283AB) | ELISA, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY829 | Anti-FER Immunohistochemistry Kit | IHC | |
| VS-0525-XY2500 | Anti-Human FER Immunohistochemistry Kit | IHC |
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