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FZD7

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. [provided by RefSeq, Jul 2008]
Protein class

G-protein coupled receptors, Human disease related genes

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Breast myoepithelial cells, Breast glandular cells, Fibroblasts, Proximal enterocytes, Cardiomyocytes)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (BJ, BJ hTERT+, CAPAN-2)

Interaction

Interacts with MAGI3 (By similarity). Interacts with DVL1 (By similarity). Interacts with CCDC88C/DAPLE; the interaction displaces DVL1 from FZD7, leading to inhibition of canonical Wnt signaling and triggering of non-canonical Wnt responses (PubMed:26126266). Interacts with MYOC (PubMed:19188438). Binds to SDCBP; this interaction is increased by inositol trisphosphate (IP3) (PubMed:27386966). Interacts with glypican GPC3 (PubMed:24496449). (Microbial infection) Interacts with C.difficile toxin TcdB; frizzled receptors constitute the major host receptors for TcdB in the colonic epithelium.

Molecular function

Developmental protein, G-protein coupled receptor, Receptor, Transducer

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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