Recombinant Anti-FZD7 Vesicular Antibody, EV Displayed (VS-0425-YC344)

CAT#: VS-0425-YC344

The Recombinant Anti-FZD7 Vesicular Antibody, EV Displayed (VS-0425-YC344) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to FZD7-expressed cells or tissues. The FZD7 is a frizzled family receptor influencing Wnt signaling and affects the beta-catenin signals in carcinoma contexts.

Gene Expression
Figure 1 IF staining of human cell line BJ Figure 2 IHC staining of human fallopian tube Figure 3 Cerebral cortex Figure 4 Colon Figure 5 Liver Figure 6 Kidney Figure 7 Testis Figure 8 RNA cell line category: Cell line enhanced (BJ, BJ hTERT+, CAPAN-2)

Recombinant Antibody

  • Application
  • ELISA, FC, Cell-uptake
  • Product Type
  • Ab-Fc-EVs
  • Antibody Quantification (Ab/EV)
  • ~100 Ab/EV
  • Target
  • FZD7
  • Host Animal
  • Mouse
  • Antibody Isotype
  • IgG
  • Species Reactivity
  • Human
  • Expression Cell
  • Mammalian cell

Engineered EVs

  • EV-sorting domain
  • CD63
  • Fc-binding domain
  • Protein A
  • EV Size
  • 30~150 nm
  • Producing Cell
  • HEK293F
  • Isolation Method
  • Gradient centrifugation
  • Purification
  • qEV size exclusion chromatography
  • Concentration
  • 1 x 10¹⁰
  • Size
  • 1 mL
  • Buffer
  • PBS
  • Storage
  • Store at -80°C for 12 months

Target

  • Full Name
  • Frizzled class receptor 7
  • Biological Process
  • Wnt signaling pathway
  • Molecular Function
  • Developmental protein, G-protein coupled receptor, Receptor, Transducer
  • Cellular Localization
  • Vesicles
  • Introduction
  • Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.
  • Alternative Names
  • FzE3
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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