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GABRA1
Loading...Anti-GABRA1 Products
- Human Anti-GABRA1 Recombinant Antibody (clone 1F4) (FAMAB-1351CQ)
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- Species Reactivity: Human
- Type: Human IgG1
- Application: FSEC
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- Rabbit Anti-GABRA1 Recombinant Antibody (VS-0223-WK23) (VS-0223-WK23)
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- Derivation: Rabbit
- Species Reactivity: Rat, Mouse
- Type: Rabbit IgG
- Application: WB, ICC, IHC, IHC-P
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- Human Anti-GABRA1 (clone A10) scFv-Fc Chimera (VS-0325-FY168)
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- Species Reactivity: Human, Rat
- Type: Human IgG1, scFv-Fc
- Application: IF, DB
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For Research Use Only. Not For Clinical Use.
This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene cause juvenile myoclonic epilepsy and childhood absence epilepsy type 4. Multiple transcript variants encoding the same protein have been identified for this gene.
Protein class
Disease related genes, FDA approved drug targets, Human disease related genes, Transporters
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Group enriched (Excitatory neurons, Inhibitory neurons, Bipolar cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Not detected
Interaction
Heteropentamer, formed by a combination of alpha, beta, gamma, delta and rho chains (PubMed:29950725, PubMed:30266951). Interacts with UBQLN1 (By similarity). Interacts with TRAK1 (By similarity). Interacts with KIF21B (By similarity). Identified in a complex of 720 kDa composed of LHFPL4, NLGN2, GABRA1, GABRB2, GABRG2 and GABRB3 (By similarity). Interacts with LHFPL4 (PubMed:28978485, PubMed:29742426). Interacts with NLGN2 (By similarity). Interacts with SHISA7; interaction leads regulation of GABA(A) receptor trafficking, channel deactivation kinetics and pharmacology (By similarity).
Molecular function
Chloride channel, Ion channel, Ligand-gated ion channel, Receptor
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