Human Anti-GABRA1 (clone A10) scFv-Fc Chimera (CAT#: VS-0325-FY168)
The anti-α1 GABAA receptor scFv-Fc antibody is a recombinant antibody fragment specifically designed to target the α1 subunit of GABAA receptors. This antibody is constructed as a single-chain variable fragment (scFv) fused to the Fc portion of human IgG, resulting in a dimeric format with enhanced binding capabilities. Initially generated against a rat α1 subunit peptide, this antibody exhibits cross-reactivity with GABAA receptors from other species, including Xenopus laevis and mouse, and is likely to also recognize human GABAA receptors due to high sequence conservation. The antibody, designated as clone A10, was generated using a synthetic peptide corresponding to residues 1-15 of the rat α1 GABAA receptor subunit (QPSQDELKDNTTVFT) as the immunogen. This anti-α1 GABAA receptor scFv-Fc antibody offers a valuable tool for researchers investigating GABAA receptor biology and exploring potential therapeutic applications.
Specific Inquiry
Normal Tissue
Figure 1 High expression in cerebral cortex
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55746/ihc_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55746/ihc_selected.jpg
Figure 2 Low expression in placenta
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55746/134315_A_3_7_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55746/134315_A_3_7_val_selected.jpg
Figure 3 Cerebral cortex
(Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuropil Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/22502/106631_B_7_5.jpg
(Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuropil Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/22502/106631_B_7_5.jpg
Specifications
- Immunogen
- Synthetic peptide corresponding to residues 1-15 of the rat α1 GABAA receptor subunit (QPSQDELKDNTTVFT).
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human GABRA1
- Species Reactivity
- Human, Rat
- Clone
- A10
- Applications
- Immunofluorescence, Dot Blot
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Gamma-Aminobutyric Acid Type A Receptor Alpha1 Subunit; Gamma-Aminobutyric Acid (GABA) A Receptor, Alpha 1; GABA(A) Receptor Subunit Alpha-1; GABA(A) Receptor, Alpha 1; Gamma-Aminobutyric Acid Receptor Subunit Alpha-1; EIEE19; ECA4; EJM5; EJM
- Gene ID
- 2554
- UniProt ID
- P14867
- Long Name
- Gamma-Aminobutyric Acid Type A Receptor Alpha1 Subunit
- Sequence Similarities
- Belongs to the ligand-gated ion channel (TC 1.A.9) family.
- Cellular Localization
- Postsynaptic cell membrane; Cell membrane
- Post Translation Modifications
- Glycosylation at Asn38 and Asn138
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 2 sites, 1 N-linked glycan (1 site)
- Protein Refseq
- NP_000797.2; NP_001121115.1; NP_001121116.1; NP_001121117.1; NP_001121120.1
- Function
- Alpha subunit of the heteropentameric ligand-gated chloride channel gated by Gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:23909897, 25489750, 29950725, 30602789).
GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (PubMed:29950725, 30602789).
When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1384 | Hi-Affi™ Rabbit Anti-GABRA1 Recombinant Antibody (clone DS1384AB) | WB, IHC-P | Rabbit IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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