Human Anti-GABRA1 (clone A10) scFv-Fc Chimera
CAT#: VS-0325-FY168
The anti-α1 GABAA receptor scFv-Fc antibody is a recombinant antibody fragment specifically designed to target the α1 subunit of GABAA receptors. This antibody is constructed as a single-chain variable fragment (scFv) fused to the Fc portion of human IgG, resulting in a dimeric format with enhanced binding capabilities. Initially generated against a rat α1 subunit peptide, this antibody exhibits cross-reactivity with GABAA receptors from other species, including Xenopus laevis and mouse, and is likely to also recognize human GABAA receptors due to high sequence conservation. The antibody, designated as clone A10, was generated using a synthetic peptide corresponding to residues 1-15 of the rat α1 GABAA receptor subunit (QPSQDELKDNTTVFT) as the immunogen. This anti-α1 GABAA receptor scFv-Fc antibody offers a valuable tool for researchers investigating GABAA receptor biology and exploring potential therapeutic applications.
Gene Expression
Normal Tissue
Figure 1 High expression in cerebral cortex
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55746/ihc_selected.jpg
Normal Tissue
Figure 2 Low expression in placenta
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55746/134315_A_3_7_val_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuropil Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/22502/106631_B_7_5.jpg
❮
❯
Specifications
- Immunogen
- Synthetic peptide corresponding to residues 1-15 of the rat α1 GABAA receptor subunit (QPSQDELKDNTTVFT).
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Antibody Isotype
- scFv-Fc
- Specificity
- Human GABRA1
- Species Reactivity
- Human, Rat
- Clone
- A10
- Applications
- Immunofluorescence, Dot Blot
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Gamma-Aminobutyric Acid Type A Receptor Alpha1 Subunit; Gamma-Aminobutyric Acid (GABA) A Receptor, Alpha 1; GABA(A) Receptor Subunit Alpha-1; GABA(A) Receptor, Alpha 1; Gamma-Aminobutyric Acid Receptor Subunit Alpha-1; EIEE19; ECA4; EJM5; EJM
- Gene ID
- 2554
- UniProt ID
- P14867
- Long Name
- Gamma-Aminobutyric Acid Type A Receptor Alpha1 Subunit
- Sequence Similarities
- Belongs to the ligand-gated ion channel (TC 1.A.9) family.
- Cellular Localization
- Postsynaptic cell membrane; Cell membrane
- Post Translation Modifications
- Glycosylation at Asn38 and Asn138
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 2 sites, 1 N-linked glycan (1 site)
- Protein Refseq
- NP_000797.2; NP_001121115.1; NP_001121116.1; NP_001121117.1; NP_001121120.1
- Function
- Alpha subunit of the heteropentameric ligand-gated chloride channel gated by Gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:23909897, 25489750, 29950725, 30602789).
GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (PubMed:29950725, 30602789).
When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient.
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for VS-0325-FY168. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "GABRA1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1384 | Hi-Affi™ Rabbit Anti-GABRA1 Recombinant Antibody (clone DS1384AB) | WB, IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-1351CQ | Human Anti-GABRA1 Recombinant Antibody (clone 1F4) | FSEC | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0223-WK23 | Rabbit Anti-GABRA1 Recombinant Antibody (VS-0223-WK23) | WB, ICC, IHC, IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC705 | Recombinant Anti-GABRA1 Vesicular Antibody, EV Displayed (VS-0425-YC705) | ELISA, FC, Cell-uptake |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: FC, Cyt, Stim, PP, Agonist
Application: WB, IF, IP, Neut, FuncS, ELISA, FC
Application: Neut, ELISA, IF, IP, FuncS, FC, IHC
Application: WB, ELISA, FC, IP, FuncS, IF, Neut
Application: FC, IP, ELISA, Neut, FuncS, IF, WB
Application: FuncS, IF, Neut, ELISA, FC, IP, IHC
Application: WB, IP, IF, FuncS, FC, Neut, ELISA
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: FC, IP, ELISA, Neut, FuncS, IF, ICC
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: WB, FuncS, IF, Neut, ELISA, FC, IP
Application: ELISA, WB, BLI, SPR
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
