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GH1

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The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature.

Protein Chemical Formula:
C990H1532N262O300S7
Protein Average Weight:
22129.0 Da
CAS Number:
12629-01-5
Pegvisomant (TP-101CL)
Protein Chemical Formula:
C990H1532N262O300S7
Protein Average Weight:
22129.0 Da
CAS Number:
218620-50-9
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
ELISA, IP, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
Fab
Application:
RIA, WB, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
scFv
Application:
FC, IP, FuncS
Species Reactivity:
Human
Type:
IgG2b
Application:
Neut, WB
Species Reactivity:
Human
Type:
IgG2
Application:
WB, Neut
Species Reactivity:
Human
Type:
Mouse antibody
Application:
ELISA, WB
Derivation:
Phage display library screening
Species Reactivity:
Cow
Type:
IgG
Application:
RIA
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