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GLI1

Recombinant Antibody Products Formats

Anti-GLI1 Recombinant Antibody Products

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For Research Use Only. Not For Clinical Use.


This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Protein class

Disease related genes, Human disease related genes, Transcription factors

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Peritubular cells, Leydig cells, Sertoli cells, Theca cells, Fibroblasts)

Immune cell specificity

Immune cell enhanced (neutrophil)

Cell line specificity

Cell line enhanced (AN3-CA, BJ hTERT+, NTERA-2, RH-30, U-266/70)

Interaction

Interacts with KIF7 (By similarity). Interacts with STK36 (PubMed:10806483). Interacts with ZIC1; the interaction enhances transcription activation (PubMed:11238441). Interacts with SUFU; this inhibits transcriptional activation by GLI1 (PubMed:10806483, PubMed:24311597, PubMed:24217340, PubMed:28965847).

Molecular function

Activator, Developmental protein, DNA-binding

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Related Signaling Pathways
Hedgehog Signaling Pathway Hedgehog Signaling Pathway
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