GM3
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Loading...- Recombinant Human Anti-GM3 Antibody (MHH-407)
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- Derivation: Human
- Type: IgG
- Application: IP, IF, Biosensors, FuncS
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- Recombinant Human Anti-GM3 Antibody (L612) (HPAB-0190CQ)
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- Derivation: EBV-transformed human B-cell line
- Type: Human IgM
- Application: ELISA, WB, Inhib
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- Human Anti-GM3 Recombinant Antibody (clone L612) (FAMAB-0055WJ)
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- Species Reactivity: Human
- Type: Human IgM
- Application: WB, FC, Cyt
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- Mouse Anti-GM3 Recombinant Antibody (clone GMR6) (VS-0224-XY52)
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- Type: Mouse IgM, kappa
- Application: ELISA, FC, IHC
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- Human Anti-GM3 Recombinant Antibody (TAB-321CL) (TAB-321CL)
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- Species Reactivity: Human
- Type: Human IgM
- Application: ELISA
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- Recombinant Mouse Anti-GM3 Antibody (MOB-0308MC)
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- Application: TLC-immunostaining, Flow cytometric analysis, Enzyme-Linked Immunosorbent, Assay, IHC
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- Human Anti-GM3 Recombinant Antibody (clone L612); Fab Fragment (FAMAB-0055WJ-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: WB
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- Human Anti-GM3 Recombinant Antibody (clone L612); scFv Fragment (FAMAB-0055WJ-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: WB
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- Recombinant Anti-GM3 Antibody Fab Fragment (MOB-407-F(E))
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- Derivation: Mouse
- Type: Fab
- Application: IF, FuncS
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- Recombinant Human Anti-GM3 Antibody Fab Fragment (MHH-407-F(E))
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- Derivation: Human
- Type: Fab
- Application: WB, IF, FuncS
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- Recombinant Human Anti-GM3 Antibody scFv Fragment (MHH-407-S(P))
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- Derivation: Human
- Type: scFv
- Application: WB, FC, FuncS
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- Recombinant Human Anti-GM3 Antibody Fab Fragment (L612) (HPAB-0190CQ-F(E))
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- Derivation: EBV-transformed human B-cell line
- Type: Human Fab
- Application: ELISA
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- Recombinant Anti-GM3 Antibody scFv Fragment (MOB-407-S(P))
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- Derivation: Mouse
- Type: scFv
- Application: WB, Neut, FuncS
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- Recombinant Human Anti-GM3 Antibody scFv Fragment (L612) (HPAB-0190CQ-S(P))
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- Derivation: EBV-transformed human B-cell line
- Type: Human scFv
- Application: ELISA
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- Mouse Anti-GM3 Antibody (14F7), CHO Stable Cell Pool (VS-1025-QX210)
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- Host Species: Mouse
- Target: GM3
- Antibody Type: Mouse IgG1, κ
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- Human Anti-GM3 Antibody (L612), CHO Stable Cell Pool (VS-1025-QX252)
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- Host Species: Human
- Target: GM3
- Antibody Type: Human IgM, κ
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For Research Use Only. Not For Clinical Use.
Background
Sialic acid-containing glycosphingolipids, known as gangliosides, have important roles in several cellular events. Gangliosides are essential components of the so-called lipid rafts, which are membrane microdomains where these glycolipids associate with proteins that participate in cell signaling cascades. The GM3(Neu5Gc) ganglioside in particular has been detected in breast cancer, melanoma, non-small cell lung cancer, Wilms tumors, neuroectodermal tumors, sarcomas and thyroid carcinomas and malignancies from the digestive and genitourinary systems. Three different immunotherapeutic approaches have focused on this molecule as their target: a molecular vaccine, an antiidiotypic antibody-based vaccine and the use of monoclonal antibodies (mAbs) able to discriminate between GM3(Neu5Gc) and GM3(Neu5Ac).