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GRN
Loading...Anti-GRN Products
- Mouse Anti-GRN Recombinant Antibody (clone 5B10) (MOB-2578z)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IHC
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ICC, IHC-P, IP, WB
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- Derivation: Phage display library
- Species Reactivity: Mouse
- Type: Rabbit IgG
- Application: ELISA
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- Anti-GRN Immunohistochemistry Kit (VS-0325-XY954)
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- Species Reactivity: Human
- Target: GRN
- Application: IHC
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- Anti-Mouse Grn Immunohistochemistry Kit (VS-0525-XY2938)
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- Species Reactivity: Mouse
- Target: Grn
- Application: IHC
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- Anti-Human GRN Immunohistochemistry Kit (VS-0525-XY2937)
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- Species Reactivity: Human
- Target: GRN
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Background
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.
Protein class
Disease related genes, Human disease related genes, Plasma proteins
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Hofbauer cells, Kupffer cells)
Immune cell specificity
Group enriched (classical monocyte, myeloid DC, plasmacytoid DC, intermediate monocyte, neutrophil, non-classical monocyte)
Cell line specificity
Low cell line specificity
Interaction
Progranulin is secreted as a homodimer (PubMed:23364791). Interacts with SLPI; interaction protects progranulin from proteolysis (PubMed:12526812). Interacts (via region corresponding to granulin-7 peptide) with CTSD; stabilizes CTSD and increases its proteolytic activity (PubMed:28453791). Interacts (via region corresponding to granulin-7 peptide) with SORT1; this interaction mediates endocytosis and lysosome delivery of progranulin; interaction occurs at the neuronal cell surface in a stressed nervous system (PubMed:21092856). Interacts with PSAP; facilitates lysosomal delivery of progranulin from the extracellular space and the biosynthetic pathway (PubMed:26370502). Forms a complex with PSAP and M6PR; PSAP bridges the binding between progranulin and M6PR (PubMed:26370502). Forms a complex with PSAP and SORT1; progranulin bridges the interaction between PSAP and SORT1; facilitates lysosomal targeting of PSAP via SORT1; interaction enhances PSAP uptake in primary cortical neurons (PubMed:28541286). Interacts (via regions corresponding to granulin-2 and granulin-7 peptides) with GBA; this interaction prevents aggregation of GBA-SCARB2 complex via interaction with HSPA1A upon stress (PubMed:27789271). Interacts (via region corresponding to granulin-7 peptide) with HSPA1A; mediates recruitment of HSPA1A to GBA and prevents GBA aggregation in response to stress (PubMed:27789271).
Molecular function
Cytokine
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