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HCK
Anti-HCK Recombinant Antibody Products
- Mouse Anti-HCK Recombinant Antibody (VS3-CJ511) (VS3-CJ511)
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- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, ICC
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- Mouse Anti-HCK Recombinant Antibody (VS3-FY2732) (VS3-FY2732)
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- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG
- Application: WB, ICC
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- Mouse Anti-HCK Recombinant Antibody (clone 40H4) (MOB-3439z)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IP, IF
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Multiple isoforms with different subcellular distributions are produced due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) codon.
Protein class
Disease related genes, Enzymes, Metabolic proteins, Potential drug targets
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (monocytes, Macrophages, Kupffer cells, Hofbauer cells, Langerhans cells, Microglial cells)
Immune cell specificity
Group enriched (non-classical monocyte, intermediate monocyte, neutrophil, eosinophil, classical monocyte, myeloid DC)
Cell line specificity
Group enriched (THP-1, U-937)
Interaction
Interacts (via SH2 domain) with FLT3 (tyrosine phosphorylated). Interacts with VAV1, WAS and RAPGEF1 (By similarity). This interaction stimulates its tyrosine-kinase activity. Interacts with ARRB1 and ARRB2. Interacts with ADAM15. Interacts with FASLG. Interacts with CBL. Interacts with FCGR1A; the interaction may be indirect. Interacts with IL6ST. Interacts (via SH3 domain) with ELMO1. Interacts (via SH3 domain) with TP73. Interacts with YAP1. Interacts with ABL1 and ITGB1, and thereby recruits ABL1 to activated ITGB1. Interacts (via SH3 domain) with WDCP. (Microbial infection) Interacts (via SH3 domain) with HEV ORF3 protein. (Microbial infection) Interacts (via SH3 domain) with HIV-1 Nef and Vif.
Molecular function
Kinase, Transferase, Tyrosine-protein kinase
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