Plasma proteins, Transcription factors
Intracellular
Cell type enhanced (Muller glia cells, Paneth cells, Undifferentiated cells, Hepatic stellate cells)
Immune cell enriched (eosinophil)
Cell line enhanced (hTCEpi, OE19, SK-BR-3)
Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family. Interacts (via WPRW motif) with TLE1, and more weakly with TLE2. Interacts with HES6 (By similarity). Interacts with SIRT1. Interacts with an FA complex, composed of FANCA, FANCF, FANCG and FANCL, but not of FANCC, nor FANCE.
DNA-binding, Repressor
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For Research Use Only. Not For Clinical Use.