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HRH3

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For Research Use Only. Not For Clinical Use.


Background

Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene encodes one of the histamine receptors (H3) which belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and can regulate neurotransmitter release. This receptor can also increase voltage-dependent calcium current in smooth muscles and innervates the blood vessels and the heart in cardiovascular system.
Protein class

FDA approved drug targets, G-protein coupled receptors

Predicted location

Membrane

Single cell type specificity

Cell type enriched (Inhibitory neurons)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enriched (SCLC-21H)

Molecular function

G-protein coupled receptor, Receptor, Transducer

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