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IL11

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For Research Use Only. Not For Clinical Use.


The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
IL11
Protein class

Cancer-related genes

Predicted location

Intracellular, Secreted (different isoforms)

Single cell type specificity

Group enriched (Pancreatic endocrine cells, Smooth muscle cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced

Interaction

Interacts with IL11RA to associate with IL6ST, giving rise to a multimeric signaling complex.

Molecular function

Cytokine, Growth factor

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