Transcription factors
Intracellular
Cell type enhanced (Bipolar cells, Enteroendocrine cells, Horizontal cells, Cytotrophoblasts, Syncytiotrophoblasts)
Not detected in immune cells
Cell line enriched (SH-SY5Y)
At neuronal promoters, displaces LDB1 from LHX3 LIM domain to form a ternary complex in which ISL1 contacts both LHX3 and LDB1. Interacts (via C-terminus) with POU4F2 (via C-terminus). Interacts with POU3F2. Interacts with POU4F3. Interacts (via N-terminal domain) with MLIP; the interaction represses ISL1 transactivator activity (By similarity).
Activator, Developmental protein, DNA-binding
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For Research Use Only. Not For Clinical Use.