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ITK
Anti-ITK Recombinant Antibody Products
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IHC, ICC, FC, ELISA
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- Mouse Anti-ITK Recombinant Antibody (clone 5G6) (VS3-XY945)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, ICC, FC
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- Rabbit Anti-ITK Recombinant Antibody (clone R04-8H3) (VS3-XY3402)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC-P, FC
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For Research Use Only. Not For Clinical Use.
This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation.
Protein class
Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets
Predicted location
Intracellular
Single cell type specificity
Group enriched (T-cells, dendritic cells, NK-cells, Plasma cells, granulocytes)
Immune cell specificity
Group enriched (naive CD4 T-cell, T-reg, naive CD8 T-cell, memory CD4 T-cell, memory CD8 T-cell, gdT-cell, NK-cell, MAIT T-cell)
Cell line specificity
Group enriched (JURKAT, MOLT-4)
Interaction
Homooligomerizes; this association negatively regulates kinase activity (By similarity). Interacts with PPIA/CYPA; this interaction regulates TCR signal strength via a proline-directed conformational switch in ITK. Interacts with THEMIS (By similarity). Interacts with FASLG. Interacts with VAV1; this interaction is important for VAV1 localization and TCR-induced actin polarization. Interacts with TBX21 (By similarity).
Molecular function
Kinase, Transferase, Tyrosine-protein kinase
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