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    KLB

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    For Research Use Only. Not For Clinical Use.


    Background

    Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21 (By similarity).
    Protein class

    Transporters

    Predicted location

    Membrane

    Single cell type specificity

    Cell type enhanced (Hepatocytes, Spermatocytes, Alveolar cells type 2, Enteroendocrine cells, Intestinal goblet cells)

    Immune cell specificity

    Not detected in immune cells

    Cell line specificity

    Group enriched (ASC diff, Hep G2)

    Interaction

    Interacts with FGFR1 and FGFR4 (By similarity). Interacts with FGF19; this interaction is direct. Interacts (via C-terminus) with FGF21; this interaction is direct.

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