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KREMEN2

Anti-KREMEN2 Products

Mouse Anti-KREMEN2 Recombinant Antibody (clone SC78.56) (HPAB-N0360-YC)
- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, FC, FuncS
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Human Anti-KREMEN2 Recombinant Antibody (clone hSC78.56sslMJ) (HPAB-N0361-YC)
- Derivation: Humanized
- Species Reactivity: Human
- Type: Human IgG1, κ (C220S, N297A)
- Application: ELISA, FC, FuncS
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Mouse Anti-KREMEN2 Recombinant Antibody (clone SC78.56); scFv Fragment (HPAB-N0360-YC-S(P))
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC
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Human Anti-KREMEN2 Recombinant Antibody (clone hSC78.56sslMJ); scFv Fragment (HPAB-N0361-YC-S(P))
- Derivation: Humanized
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, FC
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Mouse Anti-KREMEN2 Recombinant Antibody (clone SC78.56); Fab Fragment (HPAB-N0360-YC-F(E))
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC
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Human Anti-KREMEN2 Recombinant Antibody (clone hSC78.56sslMJ); Fab Fragment (HPAB-N0361-YC-F(E))
- Derivation: Humanized
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, FC
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Recombinant Anti-KREMEN2 Vesicular Antibody, EV Displayed (VS-0425-YC449) (VS-0425-YC449)
- Species Reactivity: Human
- Target: KREMEN2
- Host Animal: Human
- Application: ELISA, FC, Cell-uptake
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Hi-Affi™ Recombinant Rabbit Anti-KREMEN2 Monoclonal Antibody (DS1974AB) (MOR-1974)
- Derivation: Phage display library screening
- Species Reactivity: Mouse, Rat, Human
- Type: IgG
- Application: WB
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More Infomation

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For Research Use Only. Not For Clinical Use.

This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor. A similar protein in mouse functions interacts with with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein forms a ternary membrane complex with DKK1 and the WNT receptor lipoprotein receptor-related protein 6 (LRP6), and induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (Basal squamous epithelial cells, Spermatogonia, Basal keratinocytes, Intestinal goblet cells, Rod photoreceptor cells, Spermatocytes)

Immune cell specificity

Immune cell enhanced (naive B-cell, memory B-cell)

Cell line specificity

Cell line enhanced (HMC-1, MCF7, RPMI-8226, T-47d)

Interaction

Interacts with ERLEC1. Forms a ternary complex with DKK1 and LRP6.

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