Recombinant Anti-KREMEN2 Vesicular Antibody, EV Displayed (VS-0425-YC449)
CAT#: VS-0425-YC449
The Recombinant Anti-KREMEN2 Vesicular Antibody, EV Displayed (VS-0425-YC449) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to KREMEN2-expressed cells or tissues. The KREMEN2 is a Wnt receptor participating in signaling regulation, expressed as several transcript variants.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line RH-30
Immunofluorescent staining of human cell line RH-30 shows localization to nucleoli.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3223/if_selected.jpg
Normal Tissue
Figure 2 IHC staining of human tonsil
Immunohistochemical staining of human tonsil shows moderate cytoplasmic positivity in non-germinal center cells and subset of germinal center cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3223/ihc_selected.jpg
Normal Tissue
Figure 3 Testis
Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3223/10173_A_4_6.jpg
Normal Tissue
Figure 4 Lymph node
Germinal center cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3223/10173_A_8_8.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (HMC-1, MCF7, RPMI-8226, T-47d)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000131650-KREMEN2
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Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- KREMEN2
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Kringle containing transmembrane protein 2
- Biological Process
- Wnt signaling pathway
- Introduction
- This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor. A similar protein in mouse functions interacts with with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein forms a ternary membrane complex with DKK1 and the WNT receptor lipoprotein receptor-related protein 6 (LRP6), and induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
- Alternative Names
- KRM2, MGC10791
- Gene ID
- 79412
- UniProt ID
- Q8NCW0
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "KREMEN2"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1974 | Hi-Affi™ Recombinant Rabbit Anti-KREMEN2 Monoclonal Antibody (DS1974AB) | WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0360-YC | Mouse Anti-KREMEN2 Recombinant Antibody (clone SC78.56) | ELISA, FC, FuncS | Mouse IgG |
| HPAB-N0361-YC | Human Anti-KREMEN2 Recombinant Antibody (clone hSC78.56sslMJ) | ELISA, FC, FuncS | Human IgG1, κ (C220S, N297A) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0360-YC-S(P) | Mouse Anti-KREMEN2 Recombinant Antibody (clone SC78.56); scFv Fragment | ELISA, FC | Mouse scFv |
| HPAB-N0361-YC-S(P) | Human Anti-KREMEN2 Recombinant Antibody (clone hSC78.56sslMJ); scFv Fragment | ELISA, FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0360-YC-F(E) | Mouse Anti-KREMEN2 Recombinant Antibody (clone SC78.56); Fab Fragment | ELISA, FC | Mouse Fab |
| HPAB-N0361-YC-F(E) | Human Anti-KREMEN2 Recombinant Antibody (clone hSC78.56sslMJ); Fab Fragment | ELISA, FC | Human Fab |
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