Human Anti-KREMEN2 Recombinant Antibody (clone hSC78.56sslMJ)
CAT#: HPAB-N0361-YC
Provided are novel anti-KREMEN2 antibodies, which can be used to treat cancer.
Published Data
Gene Expression
FuncS
Figure 1 KREMEN2 antibody drug conjugates produce durable remissions in lung squamous cell carcinoma, breast, and ovarian cancer PDX-bearing mice.
FuncS
Figure 2 KREMEN2 antibody drug conjugates effectively deplete cancer stem cell populations in lung squamous cell carcinoma PDX tumors.
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Subcellular Location
Figure 1 IF staining of human cell line RH-30
Immunofluorescent staining of human cell line RH-30 shows localization to nucleoli.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3223/if_selected.jpg
Normal Tissue
Figure 2 IHC staining of human tonsil
Immunohistochemical staining of human tonsil shows moderate cytoplasmic positivity in non-germinal center cells and subset of germinal center cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3223/ihc_selected.jpg
Normal Tissue
Figure 3 Testis
Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3223/10173_A_4_6.jpg
Normal Tissue
Figure 4 Lymph node
Germinal center cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3223/10173_A_8_8.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (HMC-1, MCF7, RPMI-8226, T-47d)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000131650-KREMEN2
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Specifications
- Immunogen
- hKREMEN2 protein
- Host Species
- Human
- Derivation
- Humanized
- Type
- Human IgG1, κ (C220S, N297A)
- Specificity
- Human KREMEN2
- Species Reactivity
- Human
- Clone
- hSC78.56sslMJ
- Applications
- ELISA, FC, FuncS
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been tested for use in Functional Assay. Please see the Published Data for further information.
Target
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone hSC78.56sslMJ"
- CAT
- Product Name
See other products for "KREMEN2"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1974 | Hi-Affi™ Recombinant Rabbit Anti-KREMEN2 Monoclonal Antibody (DS1974AB) | WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0360-YC | Mouse Anti-KREMEN2 Recombinant Antibody (clone SC78.56) | ELISA, FC, FuncS | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0360-YC-S(P) | Mouse Anti-KREMEN2 Recombinant Antibody (clone SC78.56); scFv Fragment | ELISA, FC | Mouse scFv |
| HPAB-N0361-YC-S(P) | Human Anti-KREMEN2 Recombinant Antibody (clone hSC78.56sslMJ); scFv Fragment | ELISA, FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0360-YC-F(E) | Mouse Anti-KREMEN2 Recombinant Antibody (clone SC78.56); Fab Fragment | ELISA, FC | Mouse Fab |
| HPAB-N0361-YC-F(E) | Human Anti-KREMEN2 Recombinant Antibody (clone hSC78.56sslMJ); Fab Fragment | ELISA, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC449 | Recombinant Anti-KREMEN2 Vesicular Antibody, EV Displayed (VS-0425-YC449) | ELISA, FC, Cell-uptake |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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