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    Popular Searches: Recombinant Antibody MHC Tetramer T cell Receptor Scaffold Protein
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    LAT

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    For Research Use Only. Not For Clinical Use.


    Background

    lat, or Probable L-lysine-epsilon aminotransferase, is a predicted enzyme that catalyzes the transamination of L-lysine at its epsilon-amino group. This enzyme would be involved in lysine metabolism, potentially leading to its degradation or the synthesis of modified lysine derivatives in certain organisms. Its precise role requires further investigation.
    Protein class

    Disease related genes, Plasma proteins, RAS pathway related proteins

    Predicted location

    Intracellular, Membrane (different isoforms)

    Single cell type specificity

    Group enriched (NK-cells, T-cells, dendritic cells, granulocytes, Macrophages)

    Immune cell specificity

    Group enriched (T-reg, basophil, memory CD8 T-cell, gdT-cell, memory CD4 T-cell, naive CD4 T-cell, naive CD8 T-cell, MAIT T-cell, NK-cell)

    Cell line specificity

    Cell line enhanced (HEL, HMC-1, MOLT-4)

    Interaction

    When phosphorylated, interacts directly with the PIK3R1 subunit of phosphoinositide 3-kinase and the SH2 domains of GRB2, GRAP, GRAP2, PLCG1 and PLCG2. Interacts indirectly with CBL, SOS, VAV, and LCP2. Interacts with SHB, SKAP2 and CLNK (By similarity). Interacts with FCGR1A. Interacts with GRB2, PLCG1 and THEMIS upon TCR activation in thymocytes (By similarity). Interacts with THEMIS2 (By similarity).

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