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    Popular Searches: Recombinant Antibody MHC Tetramer T cell Receptor Scaffold Protein
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    LAT

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    For Research Use Only. Not For Clinical Use.


    Background

    The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement.
    Protein class

    Disease related genes, Plasma proteins, RAS pathway related proteins

    Predicted location

    Intracellular, Membrane (different isoforms)

    Single cell type specificity

    Group enriched (NK-cells, T-cells, dendritic cells, granulocytes, Macrophages)

    Immune cell specificity

    Group enriched (T-reg, basophil, memory CD8 T-cell, gdT-cell, memory CD4 T-cell, naive CD4 T-cell, naive CD8 T-cell, MAIT T-cell, NK-cell)

    Cell line specificity

    Cell line enhanced (HEL, HMC-1, MOLT-4)

    Interaction

    When phosphorylated, interacts directly with the PIK3R1 subunit of phosphoinositide 3-kinase and the SH2 domains of GRB2, GRAP, GRAP2, PLCG1 and PLCG2. Interacts indirectly with CBL, SOS, VAV, and LCP2. Interacts with SHB, SKAP2 and CLNK (By similarity). Interacts with FCGR1A. Interacts with GRB2, PLCG1 and THEMIS upon TCR activation in thymocytes (By similarity). Interacts with THEMIS2 (By similarity).

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