Intracellular, Membrane (different isoforms)
Cell type enhanced (Extravillous trophoblasts, Hepatic stellate cells, Endothelial cells, Adipocytes, Smooth muscle cells, Sertoli cells)
Immune cell enhanced (T-reg)
Group enriched (ASC diff, ASC TERT1, HSkMC, HUVEC TERT2, U-2197)
Interacts with TGFB1; associates via disulfide bonds with the Latency-associated peptide chain (LAP) regulatory chain of TGFB1, leading to regulate activation of TGF-beta-1 (PubMed:19651619, 22278742). Interacts with TGFB2 (PubMed:19651619). Interacts with TGFB3; associates via disulfide bonds with the Latency-associated peptide chain (LAP) regulatory chain of TGFB3, leading to regulate activation of TGF-beta-3 (By similarity). Interacts with LAPTM4B; decreases TGFB1 production in regulatory T-cells (PubMed:26126825).
Growth factor binding
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For Research Use Only. Not For Clinical Use.