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    LYZ

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    For Research Use Only. Not For Clinical Use.


    Background

    This gene encodes human lysozyme, whose natural substrate is the bacterial cell wall peptidoglycan (cleaving the beta[1-4]glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine). Lysozyme is one of the antimicrobial agents found in human milk, and is also present in spleen, lung, kidney, white blood cells, plasma, saliva, and tears. The protein has antibacterial activity against a number of bacterial species. Missense mutations in this gene have been identified in heritable renal amyloidosis.
    Protein class

    Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets

    Predicted location

    Secreted

    Single cell type specificity

    Cell type enhanced (monocytes, Macrophages, Langerhans cells, Pancreatic endocrine cells, Gastric mucus-secreting cells, Kupffer cells)

    Immune cell specificity

    Group enriched (classical monocyte, myeloid DC)

    Cell line specificity

    Cell line enriched (OE19)

    Interaction

    Monomer.

    Molecular function

    Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

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