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MAPKAPK2
Anti-MAPKAPK2 Recombinant Antibody Products
- Anti-MAPKAPK2 Immunohistochemistry Kit (VS-0325-XY1302)
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- Species Reactivity: Human, Mouse, Rat
- Target: MAPKAPK2
- Application: IHC
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For Research Use Only. Not For Clinical Use.
This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Protein class
Cancer-related genes, Enzymes, Metabolic proteins
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (dendritic cells)
Immune cell specificity
Immune cell enriched (plasmacytoid DC)
Cell line specificity
Low cell line specificity
Interaction
Heterodimer with p38-alpha/MAPK14; this heterodimer forms a stable complex: molecules are positioned 'face to face' so that the ATP-binding sites of both kinases are at the heterodimer interface (PubMed:12171911, PubMed:17576063, PubMed:17255097, PubMed:17480064, PubMed:17449059, PubMed:17395714). Interacts with PHC2 (PubMed:15094067). Interacts with HSF1 (PubMed:16278218).
Molecular function
Kinase, Serine/threonine-protein kinase, Transferase
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