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MXD3
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Anti-MXD3 Products
- Mouse Anti-MXD3 Recombinant Antibody (MOB-4020z) (MOB-4020z)
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- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: WB, ICC
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- Recombinant Anti-Human MXD3 Antibody Fab Fragment (MOB-4020z-F(E))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: WB, IP, FuncS
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- Recombinant Anti-Human MXD3 Antibody scFv Fragment (MOB-4020z-S(P))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: WB, FC, FuncS
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For Research Use Only. Not For Clinical Use.
Background
This gene encodes a member of the Myc superfamily of basic helix-loop-helix leucine zipper transcriptional regulators. The encoded protein forms a heterodimer with the cofactor MAX which binds specific E-box DNA motifs in the promoters of target genes and regulates their transcription. Disruption of the MAX-MXD3 complex is associated with uncontrolled cell proliferation and tumorigenesis. Transcript variants of this gene encoding different isoforms have been described. [provided by RefSeq, Dec 2008]
Protein class
Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Erythroid cells, Granulosa cells)
Immune cell specificity
Immune cell enhanced (neutrophil)
Cell line specificity
Cell line enhanced (HDLM-2)
Interaction
Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with SIN3A AND SIN3B. Interacts with RNF17 (By similarity).
Molecular function
DNA-binding, Repressor
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