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MYCN
This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Group enriched (Extravillous trophoblasts, Granulosa cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (AF22, BEWO, HMC-1, NTERA-2, RH-30, SuSa)
Interaction
Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with KDM5A, KDM5B and HUWE1. Interacts with MYCNOS. Interacts with AURKA; interaction is phospho-independent and triggers AURKA activation; AURKA competes with FBXW7 for binding to unphosphorylated MYCN but not for binding to unphosphorylated MYCN (PubMed:27837025). Interacts with FBXW7; FBXW7 competes with AURKA for binding to unphosphorylated MYCN but not for binding to phosphorylated MYCN (PubMed:27837025).
Molecular function
Activator, DNA-binding
More Types Infomation
- PE-A*02:01/Human MYCN (VILKKATEYV) MHC Tetramer (MHC-CN0320)
-
- Class: Class I
- Antigen: MYCN
- Antigen Species: Human
- Peptide: VILKKATEYV
- Conjugate: PE
- APC-A*02:01/Human MYCN (VILKKATEYV) MHC Tetramer (MHC-CN0319)
-
- Class: Class I
- Antigen: MYCN
- Antigen Species: Human
- Peptide: VILKKATEYV
- Conjugate: APC
-
- Class: Class I
- Antigen: MYCN (N-myc)
- Antigen Species: Human
- Peptide: STMPGMICK
- Conjugate: PE
-
- Class: Class I
- Antigen: MYCN (N-myc)
- Antigen Species: Human
- Peptide: STMPGMICK
- Conjugate: APC
-
- Class: Class I
- Antigen: MYCN (N-myc)
- Antigen Species: Human
- Peptide: KFELIPTPPL
- Conjugate: PE
-
- Class: Class I
- Antigen: MYCN (N-myc)
- Antigen Species: Human
- Peptide: KFELIPTPPL
- Conjugate: APC
-
- Species Reactivity: Human
- Application: WB
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: WB, IP, IF
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For Research Use Only. Not For Clinical Use.