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Anti-MYCN ProductsBackground

Anti-MYCN Products

Mouse Anti-MYCN Recombinant Antibody (clone 18H10) (MOB-3997z)
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: WB, IP, IF
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Recombinant Mouse anti-Human MYCN Monoclonal antibody (3H4) (MOB-2256CT)
- Species Reactivity: Human
- Application: WB
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APC-A*24:02/Human MYCN (N-myc) (KFELIPTPPL) MHC Tetramer (MHC-CN0131)
- Class: Class I
- Antigen: MYCN (N-myc)
- Antigen Species: Human
- Peptide: KFELIPTPPL
- Conjugate: APC
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PE-A*24:02/Human MYCN (N-myc) (KFELIPTPPL) MHC Tetramer (MHC-CN0132)
- Class: Class I
- Antigen: MYCN (N-myc)
- Antigen Species: Human
- Peptide: KFELIPTPPL
- Conjugate: PE
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APC-A*01:01/Human MYCN (N-myc) (STMPGMICK) MHC Tetramer (MHC-CN0287)
- Class: Class I
- Antigen: MYCN (N-myc)
- Antigen Species: Human
- Peptide: STMPGMICK
- Conjugate: APC
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PE-A*01:01/Human MYCN (N-myc) (STMPGMICK) MHC Tetramer (MHC-CN0288)
- Class: Class I
- Antigen: MYCN (N-myc)
- Antigen Species: Human
- Peptide: STMPGMICK
- Conjugate: PE
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APC-A*02:01/Human MYCN (VILKKATEYV) MHC Tetramer (MHC-CN0319)
- Class: Class I
- Antigen: MYCN
- Antigen Species: Human
- Peptide: VILKKATEYV
- Conjugate: APC
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PE-A*02:01/Human MYCN (VILKKATEYV) MHC Tetramer (MHC-CN0320)
- Class: Class I
- Antigen: MYCN
- Antigen Species: Human
- Peptide: VILKKATEYV
- Conjugate: PE
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Mouse Anti-MYCN Recombinant Antibody (VS3-FY2814) (VS3-FY2814)
- Species Reactivity: Human
- Type: Mouse IgG
- Application: IHC, FC, ELISA
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Mouse Anti-MYCN Recombinant Antibody (clone 2A4E9) (VS7-0425-WR449)
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: IHC, FC
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For Research Use Only. Not For Clinical Use.

Background

This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Protein class

Cancer-related genes, Disease related genes, Human disease related genes, Transcription factors

Predicted location

Intracellular

Single cell type specificity

Group enriched (Extravillous trophoblasts, Granulosa cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (AF22, BEWO, HMC-1, NTERA-2, RH-30, SuSa)

Interaction

Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with KDM5A, KDM5B and HUWE1. Interacts with MYCNOS. Interacts with AURKA; interaction is phospho-independent and triggers AURKA activation; AURKA competes with FBXW7 for binding to unphosphorylated MYCN but not for binding to unphosphorylated MYCN (PubMed:27837025). Interacts with FBXW7; FBXW7 competes with AURKA for binding to unphosphorylated MYCN but not for binding to phosphorylated MYCN (PubMed:27837025).

Molecular function

Activator, DNA-binding

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