Mouse Anti-MYCN Recombinant Antibody (VS3-FY2814) (CAT#: VS3-FY2814)

• Host Species
• Mouse

• Type
• Mouse IgG

• Specificity
• Human MYCN

• Species Reactivity
• Human

• Applications
• Immunohistochemistry, Flow cytometry, ELISA

• Conjugate
• Unconjugated, FITC

• MW
• The molecular weight of the target protein is approximately 49.5 kDa.

• Related Disease
• Feingold Syndrome 1 and Familial Retinoblastoma

• Clonality
• Monoclonal Antibody

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Immunohistochemistry: 1/50-1/200
  Flow cytometry: 1/50-1/200
  ELISA: 1/1000-1/10000

• Alternative Names
• MYCN Proto-Oncogene, BHLH Transcription Factor; V-Myc Avian Myelocytomatosis Viral Oncogene Neuroblastoma Derived Homolog; Class E Basic Helix-Loop-Helix Protein 37; BHLHe37; NMYC; Neuroblastoma-Derived V-Myc Avian Myelocytomatosis Viral Related Oncogene; N-Myc Proto-Oncogene Protein

• Gene ID
• 4613

• UniProt ID
• P04198

• Cellular Localization
• Nucleus

• Post Translation Modifications
• Phosphorylated by GSK3-beta which may promote its degradation (PubMed:24391509).
  Phosphorylated by AURKA (PubMed:27837025).
  (P04198-MYCN_HUMAN)
  Modification sites at PhosphoSitePlus (P04198)
  Modification sites at neXtProt (NX_P04198)
  Glycosylation from GlyGen (P04198) 1 site, 1 O-linked glycan (1 site)

• Protein Refseq
• XP_054198135.1; NP_001280157.1; NP_001280160.1; NP_001280162.1

• Function
• Positively regulates the transcription of MYCNOS in neuroblastoma cells.

Secondary Antibody

• 2ND-040CQ
• Goat Anti-Mouse IgG (H&L) Antibody

Isotype Control

• MRO-A1591-YJ
• Mouse IgG Isotype control, Polyclonal

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