Mouse Anti-MYCN Recombinant Antibody (VS3-FY2814) (CAT#: VS3-FY2814)
This mouse anti-MYCN recombinant monoclonal antibody has been developed to target human MYCN protein, a calculated molecular weight of the protein is about 49.5 kDa. The optimal dilution for this antibody is Immunohistochemistry (1/50-1/200), Flow cytometry (1/50-1/200) and ELISA (1/1000-1/10000).
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Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line RH-30
(Immunofluorescent staining of human cell line RH-30 shows localization to nucleoli.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/57420/1610_C12_1_selected.jpg
(Immunofluorescent staining of human cell line RH-30 shows localization to nucleoli.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/57420/1610_C12_1_selected.jpg
Figure 2 RNA cell line category: Cell line enhanced (AF22, BEWO, HMC-1, NTERA-2, RH-30, SuSa)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000134323-MYCN
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000134323-MYCN
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human MYCN
- Species Reactivity
- Human
- Applications
- Immunohistochemistry, Flow cytometry, ELISA
- Conjugate
- Unconjugated, FITC
- MW
- The molecular weight of the target protein is approximately 49.5 kDa.
- Related Disease
- Feingold Syndrome 1 and Familial Retinoblastoma
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Immunohistochemistry: 1/50-1/200
Flow cytometry: 1/50-1/200
ELISA: 1/1000-1/10000
Target
- Alternative Names
- MYCN Proto-Oncogene, BHLH Transcription Factor; V-Myc Avian Myelocytomatosis Viral Oncogene Neuroblastoma Derived Homolog; Class E Basic Helix-Loop-Helix Protein 37; BHLHe37; NMYC; Neuroblastoma-Derived V-Myc Avian Myelocytomatosis Viral Related Oncogene; N-Myc Proto-Oncogene Protein
- Gene ID
- 4613
- UniProt ID
- P04198
- Cellular Localization
- Nucleus
- Post Translation Modifications
- Phosphorylated by GSK3-beta which may promote its degradation (PubMed:24391509).
Phosphorylated by AURKA (PubMed:27837025).
(P04198-MYCN_HUMAN)
Modification sites at PhosphoSitePlus (P04198)
Modification sites at neXtProt (NX_P04198)
Glycosylation from GlyGen (P04198) 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- XP_054198135.1; NP_001280157.1; NP_001280160.1; NP_001280162.1
- Function
- Positively regulates the transcription of MYCNOS in neuroblastoma cells.
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3997z | Mouse Anti-MYCN Recombinant Antibody (clone 18H10) | WB, IP, IF | Mouse IgG2a |
| MOB-2256CT | Recombinant Mouse anti-Human MYCN Monoclonal antibody (3H4) | WB | |
| VS7-0425-WR449 | Mouse Anti-MYCN Recombinant Antibody (clone 2A4E9) | IHC, FC | Mouse IgG1 |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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