Mycobacterium tuberculosis HSP65

Mycobacterium tuberculosis HSP65 is the same heat shock protein as described above, serving as a key chaperone in Mycobacterium tuberculosis. It ensures proper protein folding and stability under host-induced stress, which is vital for bacterial persistence in intracellular environments like macrophages. Its high conservation and immunogenicity make it a target for both tuberculosis diagnosis and vaccine development. In diagnostics, the detection of HSP65-specific immune responses aids in identifying infections, while in vaccines, it aims to elicit protective immunity against Mycobacterium tuberculosis. However, its similarity to human HSP60 necessitates consideration of potential autoimmune risks, guiding the design of safe and effective HSP65-based interventions.