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NAMPT

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For Research Use Only. Not For Clinical Use.


Background

This gene encodes a protein that catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. The protein belongs to the nicotinic acid phosphoribosyltransferase (NAPRTase) family and is thought to be involved in many important biological processes, including metabolism, stress response and aging. This gene has a pseudogene on chromosome 10. [provided by RefSeq, Feb 2011]
NAMPT
Protein class

Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins

Predicted location

Intracellular, Secreted (different isoforms)

Single cell type specificity

Cell type enhanced (Langerhans cells, Macrophages, Hepatocytes)

Immune cell specificity

Immune cell enriched (neutrophil)

Cell line specificity

Cell line enhanced (HHSteC, U-87 MG)

Interaction

Homodimer.

Molecular function

Cytokine, Glycosyltransferase, Transferase

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