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NFATC3
Anti-NFATC3 Recombinant Antibody Products
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2b, κ
- Application: ELISA, ICC, IF, IHC
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- Anti-NFATC3 Immunohistochemistry Kit (VS-0325-XY1489)
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- Species Reactivity: Human, Mouse, Rat
- Target: NFATC3
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Acts as a regulator of transcriptional activation. Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2.
Protein class
Transcription factors
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (HMC-1)
Interaction
Member of the multicomponent NFATC transcription complex that consists of at least two components, a pre-existing cytoplasmic component NFATC2 and an inducible nuclear component NFATC1. Other members such as NFATC4, or members of the activating protein-1 family, MAF, GATA4 and Cbp/p300 can also bind the complex. NFATC proteins bind to DNA as monomers. Interacts with TRIM17; this interaction prevents NFATC3 nuclear localization (By similarity).
Molecular function
Activator, Developmental protein, DNA-binding
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Related Signaling Pathways
cAMP Signaling Pathway
Canonical Wnt Signaling Pathway
Non-Canonical Wnt Signaling Pathway