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NFE2L2
Loading...Anti-NFE2L2 Products
- Rabbit Anti-NFE2L2 Polyclonal Antibody (MRO-2085-CN) (MRO-2085-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
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- Rabbit Anti-NFE2L2 Polyclonal Antibody (MRO-2086-CN) (MRO-2086-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IHC, ICC, FC, ELISA
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- Rabbit Anti-NFE2L2 Recombinant Antibody (VS3-WK1002) (VS3-WK1002)
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- Derivation: Rabbit
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, ICC, IF, IHC, IP, FC
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: ICC, IF, IHC-P, IP, WB
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- Rabbit Anti-NFE2L2 Recombinant Antibody (VS13-YC794) (VS13-YC794)
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- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, IHC-P, ICC, IF, IP, ChIP
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- Mouse Anti-NFE2L2 Recombinant Antibody (clone 1A6G6) (VS7-0425-WR470)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: IHC
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- Anti-NFE2L2 Immunohistochemistry Kit (VS-0525-XY4809)
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- Species Reactivity: Human
- Target: NFE2L2
- Application: IHC
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- Anti-Mouse NFE2L2 Immunohistochemistry Kit (VS-0525-XY4810)
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- Species Reactivity: Human, Mouse, Rat
- Target: NFE2L2
- Application: IHC
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More Infomation
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For Research Use Only. Not For Clinical Use.
Background
This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been found for this gene.
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Heterodimer; heterodimerizes with small Maf proteins (By similarity). Interacts (via the bZIP domain) with MAFG and MAFK; required for binding to antioxidant response elements (AREs) on DNA (By similarity). Interacts with KEAP1; the interaction is direct and promotes ubiquitination by the BCR(KEAP1) E3 ubiquitin ligase complex (PubMed:16888629, PubMed:15601839). Forms a ternary complex with PGAM5 and KEAP1 (PubMed:18387606). Interacts with EEF1D at heat shock promoter elements (HSE) (PubMed:21597468). Interacts via its leucine-zipper domain with the coiled-coil domain of PMF1 (PubMed:11256947). Interacts with CHD6; involved in activation of the transcription (By similarity). Interacts with ESRRB; represses NFE2L2 transcriptional activity (By similarity). Interacts with MOTS-c, a peptide produced by the mitochondrially encoded 12S rRNA MT-RNR1; the interaction occurs in the nucleus following metabolic stress (PubMed:29983246). (Microbial infection) Interacts with herpes virus 8 protein LANA1.
Molecular function
Activator, DNA-binding
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