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NKX3-1
This gene encodes a homeobox-containing transcription factor. This transcription factor functions as a negative regulator of epithelial cell growth in prostate tissue. Aberrant expression of this gene is associated with prostate tumor progression. Alternate splicing results in multiple transcript variants of this gene.
Protein class
Cancer-related genes, Human disease related genes, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Group enriched (Prostatic glandular cells, Basal prostatic cells)
Immune cell specificity
Group enriched (eosinophil, neutrophil)
Cell line specificity
Cell line enhanced (GAMG, SiHa, U-138 MG, U-251 MG)
Interaction
Interacts with serum response factor (SRF) (By similarity). Interacts with SPDEF (PubMed:11809674). Interacts with WDR77 (PubMed:12972618). Interacts with TOPORS which polyubiquitinates NKX3-1 and induces its proteasomal degradation (PubMed:18077445). Interacts with FEM1B (By similarity).
Molecular function
DNA-binding, Repressor
More Types Infomation
- Recombinant Mouse Anti-Human NKX3-1 Antibody (MOB-1727MZ)
-
- Species Reactivity: Human
- Type: Mouse antibody
- Application: WB
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC-P
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For Research Use Only. Not For Clinical Use.