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NUMB

Anti-NUMB Products

Recombinant Rabbit Anti-NUMB Monoclonal Antibody (JM10-023) (MRO-1119-CN)
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC
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Rabbit Anti-NUMB Recombinant Antibody (clone JM10-023) (VS3-WK527)
- Derivation: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, ICC, IHC
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Recombinant Rabbit Anti-NUMB Antibody (clone R09-2I5) (VS3-FY1077)
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC-P, IP
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AbPlus™ Anti-NUMB Magnetic Beads (VS-0724-YC153) (VS-0724-YC153)
- Target: NUMB
- Target Species: Human, Mouse
- Application: IP, Protein Purification
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Rabbit Anti-NHP NUMB Recombinant Antibody (clone T.873.4) (VS-1024-XY350)
- Species Reactivity: Human, Mouse, Non-human primate, Rat
- Type: Rabbit IgG
- Application: WB, IF, IP
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Rabbit Anti-NUMB Recombinant Antibody (VS13-YC851) (VS13-YC851)
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, ICC, IF, IHC-P
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Anti-NUMB Immunohistochemistry Kit (VS-0525-XY5046)
- Species Reactivity: Human
- Target: NUMB
- Application: IHC
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Anti-Mouse NUMB Immunohistochemistry Kit (VS-0525-XY5047)
- Species Reactivity: Human, Mouse, Rat
- Target: NUMB
- Application: IHC
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Hi-Affi™ Recombinant Rabbit Anti-NUMB Monoclonal Antibody (DS2520AB) (MOR-2520)
- Derivation: Phage display library screening
- Species Reactivity: Mouse, Rat, Human
- Type: IgG
- Application: WB
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For Research Use Only. Not For Clinical Use.

The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Protein class

Cancer-related genes

Predicted location

Intracellular

Single cell type specificity

Low cell type specificity

Immune cell specificity

Immune cell enhanced (neutrophil)

Cell line specificity

Low cell line specificity

Interaction

Interacts with SIAH1 (PubMed:11752454). Interacts with LNX (By similarity). Interacts with CDH1 (By similarity). Interacts with TFAP2A and TFAP2B (By similarity). Interacts with RALBP1 in a complex also containing EPN1 and TFAP2A during interphase and mitosis (PubMed:12775724). Interacts with AAK1 (PubMed:18657069). May interact with DUOXA1 (PubMed:14670962).

Molecular function

Developmental protein

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