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PAK6
Anti-PAK6 Recombinant Antibody Products
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For Research Use Only. Not For Clinical Use.
This gene encodes a member of a family of p21-stimulated serine/threonine protein kinases, which contain an amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. These kinases function in a number of cellular processes, including cytoskeleton rearrangement, apoptosis, and the mitogen-activated protein (MAP) kinase signaling pathway. The protein encoded by this gene interacts with androgen receptor (AR) and translocates to the nucleus, where it is involved in transcriptional regulation. Changes in expression of this gene have been linked to prostate cancer. Alternative splicing results in multiple transcript variants.
Protein class
Enzymes, Metabolic proteins, Plasma proteins, RAS pathway related proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Cytotrophoblasts, Suprabasal keratinocytes, NK-cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (CACO-2, HaCaT, hTCEpi)
Interaction
Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1 (By similarity). Interacts with the androgen receptor AR and the estrogen receptor ESR1. Interacts with IQGAP1 and PPM1B.
Molecular function
Kinase, Serine/threonine-protein kinase, Transferase
More Types Infomation
Related Diseases
Bladder Cancer
Related Signaling Pathways
ErbB Signaling Pathway