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PCK1
Anti-PCK1 Recombinant Antibody Products
- AbPlus™ Anti-PCK1 Magnetic Beads (VS-0724-YC576) (VS-0724-YC576)
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- Target: PCK1
- Target Species: Human
- Application: IP, Protein Purification
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For Research Use Only. Not For Clinical Use.
This gene is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. Defects in this gene are a cause of cytosolic phosphoenolpyruvate carboxykinase deficiency. A mitochondrial isozyme of the encoded protein also has been characterized. [provided by RefSeq, Jul 2008]
Protein class
Citric acid cycle related proteins, Disease related genes, Enzymes, Metabolic proteins, Potential drug targets
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Proximal tubular cells, Proximal enterocytes, Hepatocytes, Distal enterocytes, Distal tubular cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enriched (ASC diff)
Interaction
Monomer.
Molecular function
Decarboxylase, Kinase, Lyase, Transferase
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Related Signaling Pathways
BCR Signaling Pathway