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PDE6G
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For Research Use Only. Not For Clinical Use.
This gene encodes the gamma subunit of cyclic GMP-phosphodiesterase, which is composed of alpha- and beta- catalytic subunits and two identical, inhibitory gamma subunits. This gene is expressed in rod photoreceptors and functions in the phototransduction signaling cascade. It is also expressed in a variety of other tissues, and has been shown to regulate the c-Src protein kinase and G-protein-coupled receptor kinase 2. Alternative splicing results in multiple transcript variants.
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets
Predicted location
Intracellular
Single cell type specificity
Cell type enriched (Rod photoreceptor cells)
Immune cell specificity
Group enriched (NK-cell, basophil)
Cell line specificity
Cell line enhanced (Hep G2, NB-4, NTERA-2, REH, SuSa)
Interaction
Oligomer composed of two catalytic chains (alpha and beta), an inhibitory chain (gamma) and the delta chain.
Molecular function
Hydrolase
More Types Infomation
Related Signaling Pathways
cAMP Signaling Pathway
Canonical Wnt Signaling Pathway
Non-Canonical Wnt Signaling Pathway