Anti-PDK2 Recombinant Antibody Products

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For Research Use Only. Not For Clinical Use.


Creative Biolabs is proud to present its cutting-edge anti-PDK2 recombinant antibody products, meticulously developed to meet the rigorous demands of global researchers. Our advanced antibody solutions offer unparalleled specificity and reliability, empowering your studies in metabolic regulation, cancer biology, and beyond. Experience the difference of premium quality and robust performance in your critical research.

PDK2: A Pivotal Target for Metabolic Disorders and Cancer Therapy

Pyruvate Dehydrogenase Kinase 2 (PDK2) is a crucial mitochondrial enzyme that phosphorylates and inactivates the pyruvate dehydrogenase complex (PDC), a key regulator of glucose metabolism. Extensive research highlights PDK2's significant role in shifting cellular metabolism from oxidative phosphorylation to glycolysis, a hallmark of many cancers and metabolic diseases like diabetes. Understanding and targeting PDK2 is therefore vital for developing novel therapeutic strategies for these pervasive conditions.

Alternative Names

Pyruvate dehydrogenase kinase isoform 2; pyruvate dehydrogenase lipoamide kinase isozyme 2; PDHK2; PDKII.

Background

This gene encodes a member of the pyruvate dehydrogenase kinase family. The encoded protein phosphorylates pyruvate dehydrogenase, down-regulating the activity of the mitochondrial pyruvate dehydrogenase complex. Overexpression of this gene may play a role in both cancer and diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010].

Protein class

Enzymes, Metabolic proteins

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Proximal tubular cells, Proximal enterocytes)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Low cell line specificity

Interaction

Homodimer, and heterodimer with PDK1. Interacts with the pyruvate dehydrogenase complex subunit DLAT, and is part of the multimeric pyruvate dehydrogenase complex that contains multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (DLAT, E2) and lipoamide dehydrogenase (DLD, E3).

Molecular function

Kinase, Transferase

More Types Infomation

Anti-PDK2 rAb Products

Our anti-PDK2 recombinant antibody products are engineered with superior precision, offering exceptional affinity and specificity for the PDK2 protein. Produced using advanced recombinant technology, these antibodies ensure lot-to-lot consistency and minimal batch variation, critical for reproducible research outcomes. Their high purity and robust performance make them ideal tools for a wide range of applications, from Western blotting to immunohistochemistry and functional assays.

Cat. No. Product Name Target Species Host Species Applications
VS3-FY1120 Recombinant Rabbit Anti-PDK2 Antibody (clone R01-6D8) Human Human IgG1 - kappa WB, IHC-P, IP
MRO-1199-CN Recombinant Rabbit Anti-PDK2 Monoclonal Antibody (JB66-93) Human Mouse IgG WB, IHC, FC, IP
VS3-QX862 Mouse Anti-PDK2 Recombinant Antibody (clone 180CT10.2.3) Human, Mouse Mouse IgG1, κ WB, IHC
MOB-1050MZ Recombinant Mouse Anti-Human PDK2 Antibody Human Mouse antibody WB
VS3-XY3460 Rabbit Anti-PDK2 Recombinant Antibody (clone R01-5X9) Human, Mouse, Rat Rabbit IgG WB, IHC-P, ICC, IF, IP, FC

Table 1. Featured anti-PDK2 recombinant antibody products at Creative Biolabs. Creative Quality Control

Creative Quality Control

At Creative Biolabs, quality is paramount. Our anti-PDK2 recombinant antibodies undergo rigorous, multi-faceted quality control measures, including comprehensive specificity testing, binding affinity validation, and functional assessments. Each product is meticulously characterized to guarantee optimal performance and reliability, providing researchers with complete confidence in their experimental results. This commitment ensures you receive only the highest-grade reagents for your valuable work.

WB analysis. (Creative Biolabs Original)Fig.1 WB analysis of anti-PDK2 antibody
(Cat# VS3-FY1120, Creative Biolabs).

Customer Reviews

Excellent
Dr. Anya Sharma, Lead Scientist
Recombinant Rabbit Anti-PDK2 Antibody (clone R01-6D8) (VS3-FY1120)
The anti-PDK2 recombinant antibody from Creative Biolabs has been a game-changer for our metabolism research. Its exceptional specificity and low background noise significantly improved our Western blot results, saving us considerable time and resources. The consistency across different lots is truly impressive, allowing for highly reproducible experiments. A truly reliable product.
29/Oct/2024
Excellent
Professor Ben Carter, Principal Investigator
Rabbit Anti-PDK2 Recombinant Antibody (clone R01-5X9) (VS3-XY3460)
We've used Creative Biolabs' anti-PDK2 antibody for immunohistochemistry on patient samples, and the staining quality is outstanding. The signal-to-noise ratio is excellent, and the antibody consistently delivers clear, interpretable results. It has become an indispensable tool in our cancer biomarker discovery pipeline, providing the clarity we need for precise localization studies.
20/Dec/2024
Excellent
Ms. Chloe Davis, Research Associate
Rabbit Anti-PDK2 Recombinant Antibody (clone R01-5X9) (VS3-XY3460)
The technical support from Creative Biolabs, coupled with the high performance of their anti-PDK2 recombinant antibody, made our project much smoother. We successfully applied it in co-immunoprecipitation experiments, yielding robust and consistent protein interactions. This product's reliability and the team's expertise have made Creative Biolabs our preferred partner for antibody solutions.
7/May/2025

rAb Production

The production of our anti-PDK2 recombinant antibodies leverages state-of-the-art expression systems and purification techniques, ensuring high yield and unmatched purity. Our streamlined, controlled manufacturing process adheres to stringent quality standards, minimizing contaminants and maximizing antibody integrity. This advanced production pipeline guarantees that every antibody delivered is of the highest possible quality, ready for your most demanding applications.

Featured Anti-PDK2 Recombinant Antibody Production PlatformsMilligram-scale. (Creative Biolabs Original)
Fig.2 Milligram-scale anti-PDK2 recombinant antibody production.

Gram-scale. (Creative Biolabs Original)Fig.3 Gram-scale anti-PDK2 recombinant antibody production.

rAb Modalities

Creative Biolabs offers anti-PDK2 recombinant antibodies in multiple modalities, including unconjugated, biotin-conjugated, and various fluorescent-labeled formats, providing versatility for diverse experimental designs.

PDK2 antibody production and modalities. (Creative Biolabs Original)Fig.4 Full-length anti-PDK2 recombinant antibody production and modalities.

Discover the transformative potential of Creative Biolabs' anti-PDK2 recombinant antibody products for your research. Our dedicated team is ready to assist you in selecting the ideal solution to accelerate your scientific breakthroughs. Contact us today to learn more about our comprehensive product portfolio and how we can support your next project.

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