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PDPK1
Anti-PDPK1 Recombinant Antibody Products
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- Derivation: Mouse
- Species Reactivity: Human, Mouse, Monkey, Rat
- Type: Mouse IgG1
- Application: WB, ICC, IHC, FC
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- Mouse Anti-PDPK1 Recombinant Antibody (clone 3B11H2) (VS3-XY1234)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, FC, ICC
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- Mouse Anti-PDPK1 Recombinant Antibody (clone 3H6) (VS3-XY1235)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, FC, ICC, IHC
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA, FC, IF, IHC
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- Mouse Anti-NHP PDPK1 Recombinant Antibody (clone 7E4G11) (VS-1024-XY376)
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- Species Reactivity: Human, Mouse, Non-human primate, Rat
- Type: Mouse IgG1
- Application: WB, IHC, FC, ELISA
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For Research Use Only. Not For Clinical Use.
Enables 3-phosphoinositide-dependent protein kinase activity; phospholipase activator activity; and phospholipase binding activity.
Protein class
Enzymes, Metabolic proteins, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Homodimer in its autoinhibited state. Active as monomer. Interacts with NPRL2, PPARG, PAK1, PTK2B, GRB14, PKN1 (via C-terminus), STRAP and IKKB. The Tyr-9 phosphorylated form interacts with SRC, RASA1 and CRK (via their SH2 domains). Interacts with SGK3 in a phosphorylation-dependent manner. The tyrosine-phosphorylated form interacts with PTPN6. The Ser-241 phosphorylated form interacts with YWHAH and YWHAQ. Binds INSR in response to insulin. Interacts (via PH domain) with SMAD3, SMAD4 and SMAD7. Interacts with PKN2; the interaction stimulates PDPK1 autophosphorylation, its PI(3,4,5)P3-dependent kinase activity toward 'Ser-473' of AKT1 but also activates its kinase activity toward PRKCD and PRKCZ.
Molecular function
Activator, Kinase, Serine/threonine-protein kinase, Transferase
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Related Signaling Pathways
Insulin Signaling Pathway