Anti-PDPK1 Recombinant Antibody Products

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Anti-PDPK1 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs offers premium recombinant antibodies against PDPK1, tailored to support cutting-edge biomedical research. Leveraging advanced technology platforms, we deliver products that consistently uphold rigorous quality and performance benchmarks. Our diverse antibody portfolio is crafted to provide researchers with dependable, high-impact tools for their experimental needs. Beyond product excellence, we're committed to offering expert technical guidance to ensure smooth and successful project execution. Partnering with Creative Biolabs means accessing innovative reagents backed by a team dedicated to your scientific progress.

PDPK1: A Crucial target in Autoimmune Disorders and Inflammatory Diseases

PDPK1, a master regulator of the PI3K/AKT/mTOR pathway, plays a pivotal role in multiple pathological conditions due to its central role in cellular signaling. In cancer, hyperactivation of this kinase promotes uncontrolled proliferation, survival, and metastasis by enhancing downstream oncogenic cascades, particularly in breast, prostate, and hematological malignancies, where it drives resistance to chemotherapy and targeted therapies. Beyond oncology, dysregulated activity contributes to metabolic disorders such as diabetes by impairing insulin signaling and glucose homeostasis. Additionally, aberrant function has been implicated in neurodegenerative diseases, where disrupted kinase signaling exacerbates neuronal apoptosis and synaptic dysfunction. In autoimmune disorders, excessive activation fuels inflammatory responses by modulating immune cell activation and cytokine production. Given its broad pathological influence, therapeutic targeting holds promise for treating diverse diseases, particularly in oncology, where selective inhibition may overcome drug resistance while sparing normal tissues.

Alternative Names

Complement 3-Phosphoinositide Dependent Protein Kinase 1; EC 2.7.11.1; PDK1; 3-Phosphoinositide-Dependent Protein Kinase 2 Pseudogene; 3-Phosphoinositide-Dependent Protein Kinase 1; PkB Kinase Like Gene 1; PkB Kinase

Background

Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases. Its targets include: protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), p70 ribosomal protein S6 kinase (RPS6KB1), p90 ribosomal protein S6 kinase (RPS6KA1, RPS6KA2 and RPS6KA3), cyclic AMP-dependent protein kinase (PRKACA), protein kinase C (PRKCD and PRKCZ), serum and glucocorticoid-inducible kinase (SGK1, SGK2 and SGK3), p21-activated kinase-1 (PAK1), protein kinase PKN (PKN1 and PKN2). Plays a central role in the transduction of signals from insulin by providing the activating phosphorylation to PKB/AKT1, thus propagating the signal to downstream targets controlling cell proliferation and survival, as well as glucose and amino acid uptake and storage. Negatively regulates the TGF-beta-induced signaling by: modulating the association of SMAD3 and SMAD7 with TGF-beta receptor, phosphorylating SMAD2, SMAD3, SMAD4 and SMAD7, preventing the nuclear translocation of SMAD3 and SMAD4 and the translocation of SMAD7 from the nucleus to the cytoplasm in response to TGF-beta. Activates PPARG transcriptional activity and promotes adipocyte differentiation. Activates the NF-kappa-B pathway via phosphorylation of IKKB. The tyrosine phosphorylated form is crucial for the regulation of focal adhesions by angiotensin II. Controls proliferation, survival, and growth of developing pancreatic cells. Participates in the regulation of Ca(2+) entry and Ca(2+)-activated K(+) channels of mast cells. Essential for the motility of vascular endothelial cells (ECs) and is involved in the regulation of their chemotaxis. Plays a critical role in cardiac homeostasis by serving as a dual effector for cell survival and beta-adrenergic response. Plays an important role during thymocyte development by regulating the expression of key nutrient receptors on the surface of pre-T cells and mediating Notch-induced cell growth and proliferative responses. Provides negative feedback inhibition to toll-like receptor-mediated NF-kappa-B activation in macrophages. Isoform 3 is catalytically inactive.

Anti-PDPK1 rAb Products

Our commitment to accelerating research and discovery is demonstrated through the provision of high-quality anti-PDPK1 recombinant antibody products, offering exceptional value alongside superior technical support.

Table 1. Featured anti-PDPK1 recombinant antibody products at Creative Biolabs.

Creative Quality Control

To support the advancement of biopharmaceutical R&D through to market launch, we adhere to a customer-centric philosophy that prioritizes exceptional product quality. A robust quality assurance system is firmly established to maintain high standards across our offerings. By consistently aligning with — and often exceeding — client expectations, we strive to streamline the drug development process and reduce time to market.

Customer Reviews

Excellent

Ez**l
Recombinant Rabbit Anti-PDPK1 Antibody (clone R03-7H6) (CAT#: VS3-FY1121)

This antibody works well in WB on human and mouse cell lysates, detecting a clear band at the expected size. I tested it in HEK293 and MCF-7 cells, and the signal was strong with minimal background. It also performed decently in IF on fixed cells, though optimization was needed for best results. The specificity seems good, as knockdown experiments reduced the signal. However, I haven't tried it in IHC yet. Overall, a reliable option for WB and IF applications.

03/Oct/2024

Excellent

D**an
Recombinant Rabbit Anti-PDPK1 Monoclonal Antibody (CBACN-440) (CAT#: MRO-1201-CN)

I found Recombinant Rabbit Anti - PDPK1 Monoclonal Antibody reliable. Tested on HEK293 cells and mouse brain tissue, it worked well in IF with clear staining. Also used in WB showing specific bands. The antibody offered consistent performance across applications, and the technical support was helpful.

21/Jul/2023

Excellent

Ju**r
Mouse Anti-PDPK1 Recombinant Antibody (clone 29H1) (CAT#: MOB-2837z)

I used the Mouse Anti-PDPK1 Recombinant Antibody for flow cytometry on human Jurkat cells. The signal was clean and reproducible, with low background. Antibody handling was straightforward, and staining results were reliable across tests. Overall, a dependable choice for FC analysis of PDPK1.

15/Apr/2023

rAb Production

We have developed extensive expertise over the years in recombinant antibody production and optimization. Through our exceptional service, we deliver recombinant antibody products of superior quality and reliability within the shortest timeframe.

Featured Anti-PDPK1 Recombinant Antibody Production Platforms
Fig.2 Milligram-scale recombinant antibody production.

Fig.3 Gram-scale recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to providing researchers with the broadest and most advanced high-quality recombinant antibodies in diverse formats. Our expertise in recombinant antibodies spans various engineering methodologies, and our products are supported by exceptional custom engineering services designed to meet your specific requirements.

Fig.4 Full Length Anti-PDPK1 Recombinant Antibody Production and Modalities.

For further details on PDPK1, please don't hesitate to contact our technical support team by phone or email. We're happy to provide guidance and troubleshooting assistance to help optimize your experimental workflow and achieve reliable results. Let us know how we can support your research.

Related Signaling Pathways

Insulin Signaling Pathway