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PKN2
Anti-PKN2 Recombinant Antibody Products
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- Derivation: Mouse
- Species Reactivity: Human, Monkey, Mouse, Rat
- Type: Mouse IgG1
- Application: WB, IHC, ICC, FC, ELISA
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC-P, ICC, IF, IP, FC
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- Recombinant Mouse Anti-Human PKN2 Antibody (MOB-0782MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: WB
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- Mouse Anti-NHP PKN2 Recombinant Antibody (clone 1D1) (VS-1024-XY394)
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- Species Reactivity: Human, Mouse, Non-human primate, Rat
- Type: Mouse IgG1
- Application: WB, IHC, IF, FC, ELISA
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For Research Use Only. Not For Clinical Use.
Enables RNA polymerase binding activity; histone deacetylase binding activity; and protein serine/threonine kinase activity. Involved in several processes, including apical junction assembly; positive regulation of cell cycle; and positive regulation of viral genome replication. Located in several cellular components, including cleavage furrow; cytoskeleton; and midbody.
Protein class
Enzymes, Metabolic proteins, Plasma proteins
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Low cell type specificity
Immune cell specificity
Immune cell enriched (neutrophil)
Cell line specificity
Low cell line specificity
Interaction
Interacts (via the REM repeats) with RHOA (GTP-bound form preferentially) and interacts (via the REM repeats) with RAC1 (GTP-bound form preferentially); the interactions induce its autophosphorylation (PubMed:9121475, 20974804). Interacts with RHOC (PubMed:20974804). Interacts with NCK1 and NCK2 (PubMed:10026169). Interacts with NCK1 (via SH3 domains) (By similarity). Interacts with CD44 (PubMed:15123640). Interacts (via C-terminal kinase domain) with PDPK1; the interaction stimulates PDPK1 kinase activity (PubMed:10226025, 10792047, 11781095, 18835241). Interacts with MAP3K2; the interaction activates PRK2 kinase activity in a MAP3K2-independent kinase activity (PubMed:10818102). Interacts (via C-terminal domain) with AKT1; the interaction occurs with the C-terminal cleavage product of PRK2 in apoptotic cells (PubMed:10926925). Interacts (via C-terminus) with PTPN13 (via PDZ 3 domain) (PubMed:11356191). Interacts with CDK10 (PubMed:27104747). (Microbial infection) Interacts with HCV NS5B (via N-terminal finger domain).
Molecular function
Kinase, Serine/threonine-protein kinase, Transferase
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