Rabbit Anti-PKN2 Recombinant Antibody (clone R02-5K8)
CAT#: VS3-XY3467
The antibody is a recombinant rabbit antibody against human PKN2 (Protein kinase N2), which plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly and cell migration. The antibody also has cross-reactivity against mouse and rat PKN2. It has been reported for use in Western Blot, Immunohistochemistry-Paraffin, Immunoprecipitation, Flow cytometry, Immunocytochemistry or Immunofluorescence.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & intermediate filaments.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/34861/if_selected.jpg
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Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat PKN2
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R02-5K8
- Applications
- WB, IHC-P, ICC, IF, IP, FC
- Related Disease
- Renal Malformations; Bubonic Plague
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IHC: 1/50-1/100
IF: 1/50-1/200
IP: 1/20
FC: 1/50-1/100
Target
- Alternative Names
- PAK2; PRK2; STK7; Pak-2; PRKCL2; PRO2042
- Gene ID
- 5586
- UniProt ID
- Q16513
- Long Name
- Protein kinase N2
- Sequence Similarities
- Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
- Cellular Localization
- Cell junction, Cell projection, Cytoplasm, Cytoskeleton, Membrane, Nucleus
- Post Translation Modifications
- Autophosphorylated. Phosphorylated during mitosis. Phosphorylated by CDK10 (PubMed:27104747).
Activated by limited proteolysis with trypsin (By similarity).
Proteolytically cleaved by caspase-3 during the induction of apoptotic cell death.
- Protein Refseq
- NP_001307636.1; NP_001307637.1; NP_001307638.1
- Function
- PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "PKN2"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0782MZ | Recombinant Mouse Anti-Human PKN2 Antibody | WB | Mouse antibody |
| VS3-QX883 | Mouse Anti-PKN2 Recombinant Antibody (clone 4C2-B2-A0) | WB, IHC, ICC, FC, ELISA | Mouse IgG1 |
| VS4-CJ77 | Recombinant Rabbit Anti-PKN2 Antibody (clone 20A8) | ELISA, WB, IHC, IF, FC | Rabbit IgG |
| VS7-0425-WR622 | Mouse Anti-PKN2 Monoclonal Antibody (VS7-0425-WR622) | WB, IHC-P, IF, FC, ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2727 | Hi-Affi™ Recombinant Rabbit Anti-PKN2 Monoclonal Antibody (DS2727AB) | WB, IHC-P, ICC, FC, IP | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY394 | Mouse Anti-NHP PKN2 Recombinant Antibody (clone 1D1) | WB, IHC, IF, FC, ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1665 | Anti-PKN2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY5449 | Anti-Human PKN2 Immunohistochemistry Kit | IHC |
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