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POU2F1
Loading...Anti-POU2F1 Products
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- Derivation: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, ELISA
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- Anti-POU2F1 Immunohistochemistry Kit (VS-0525-XY5581)
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- Species Reactivity: Human
- Target: POU2F1
- Application: IHC
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For Research Use Only. Not For Clinical Use.
The OCT1 transcription factor was among the first identified members of the POU transcription factor family (summarized by Sturm et al., 1993 [PubMed 8314572]). Members of this family contain the POU domain, a 160-amino acid region necessary for DNA binding to the octameric sequence ATGCAAAT.
Protein class
Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Astrocytes, Oligodendrocytes, Excitatory neurons, Oligodendrocyte precursor cells, Inhibitory neurons)
Immune cell specificity
Immune cell enhanced (basophil)
Cell line specificity
Low cell line specificity
Interaction
Interacts with POU2AF1; the interaction increases POU2F1 transactivation activity (PubMed:7859290). Interacts with NR3C1, AR, PGR and HCFC1. (Microbial infection) Associates with the herpes simplex virus VP16-induced complex; binding to HCFC1 activates the viral transcriptional activator VP16 for association with POU2F1, to form a multiprotein-DNA complex responsible for activating transcription of the viral immediate early genes.
Molecular function
Activator, DNA-binding
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