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PPIA
Loading...Anti-PPIA Products
- Rabbit Anti-PPIA Recombinant Antibody (clone CBP271) (MOB-286YJL)
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- Species Reactivity: Mouse
- Type: Rabbit IgG
- Application: ELISA
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- AbPlus™ Anti-PPIA Magnetic Beads (VS-0724-YC1153) (VS-0724-YC1153)
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- Target: PPIA
- Target Species: Human
- Application: IP, Protein Purification
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- AbPlus™ Anti-Ppia Magnetic Beads (VS-0724-YC1230) (VS-0724-YC1230)
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- Target: Ppia
- Target Species: Mouse
- Application: IP, Protein Purification
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB
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- Rabbit Anti-PPIA Recombinant Antibody (VS13-YC922) (VS13-YC922)
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- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, IHC-P
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- Anti-PPIA Immunohistochemistry Kit (VS-0325-XY1708)
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- Species Reactivity: Human
- Target: PPIA
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Background
Peptidylprolyl isomerase A (PPIA), also known as cyclophilin A (CypA) or rotamase A is an enzyme that in humans is encoded by the PPIA gene on chromosome 7. As a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family, this protein catalyzes the cis-trans isomerization of proline imidic peptide bonds, which allows it to regulate many biological processes, including intracellular signaling, transcription, inflammation, and apoptosis. Due to its various functions, PPIA has been implicated in a broad range of inflammatory diseases, including atherosclerosis and arthritis, and viral infections.
Protein class
Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Interacts with protein phosphatase PPP3CA/calcineurin A (PubMed:12218175, 12357034). Interacts with PRPF19 isoform 2 (via N-terminus) (By similarity). Interacts with isoform 2 of BSG/CD147 (PubMed:15688292, 11353871, 11943775, 21245143). Interacts with FOXO1; the interaction promotes FOXO1 dephosphorylation, nuclear accumulation and transcriptional activity (PubMed:31063815). Interacts with integrin ITGA2B:ITGB3; the interaction is ROS and peptidyl-prolyl cis-trans isomerase (PPIase) activity-dependent and is increased in the presence of thrombin (By similarity). Interacts with MAP3K5 (PubMed:26095851). Interacts with TARDBP; the interaction is dependent on the RNA-binding activity of TARDBP and the PPIase activity of PPIA/CYPA and the acetylation of PPIA/CYPA at Lys-125 favors the interaction (PubMed:25678563). Interacts with HNRNPA1, HNRNPA2B1, HNRNPC, RBMX, HNRNPK and HNRNPM (PubMed:25678563). (Microbial infection) Interacts with HIV-1 capsid protein (PubMed:20364129, 8513493). (Microbial infection) Interacts with human SARS coronavirus nucleoprotein. (Microbial infection) Interacts with measles virus nucleoprotein. (Microbial infection) Interacts with influenza A virus matrix protein 1. (Microbial infection) Interacts with HCV NS5A; the interaction stimulates RNA-binding ability of NS5A and is dependent on the peptidyl-prolyl cis-trans isomerase activity of PPIA/CYPA.
Molecular function
Isomerase, Rotamase
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