Anti-PRKAB1 Recombinant Antibody Products

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Anti-PRKAB1 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs provides internationally acclaimed, cutting-edge recombinant antibodies targeting PRKAB1, designed as essential instruments to propel biomedical research forward. Utilizing state-of-the-art technological platforms, we ensure every product meets the highest standards of quality and functional performance. Our commitment to accelerating scientific breakthroughs is reflected in our extensive range of recombinant reagents, each crafted to offer exceptional reliability and cost-effectiveness. Beyond delivering superior antibodies, we are dedicated to providing outstanding technical support customized to assist researchers throughout all stages of their projects. Partnering with Creative Biolabs means gaining not only innovative research tools but also a committed collaborator focused on advancing your scientific goals efficiently and effectively.

PRKAB1: A Key Metabolic Sensor and Therapeutic Target in Multiple Diseases

PRKAB1, a key regulatory component of AMP-activated protein kinase, functions as an essential metabolic sensor involved in various disease mechanisms. Impairment of this subunit disrupts cellular energy balance, contributing to metabolic disorders such as diabetes and obesity by affecting glucose transport and lipid processing. In oncology, abnormal PRKAB1 signaling supports tumor survival by altering nutrient metabolism under low-oxygen conditions. Cardiovascular diseases, including ischemic heart conditions and atherosclerosis, are worsened by its dysregulated activity, impacting endothelial health and vascular remodeling processes. Neurodegenerative disorders like Parkinson’s disease may result from faulty neuronal energy management, causing oxidative damage and protein aggregation. Moreover, PRKAB1 influences inflammatory pathways, linking it to autoimmune disorders and chronic inflammatory states. While targeting this pathway offers promising therapeutic avenues to reestablish metabolic homeostasis across these diverse illnesses, achieving precise control remains difficult due to its complex, tissue-specific functions and effects.

Alternative Names

Complement AMPK; HAMPKb

Background

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex.

Anti-PRKAB1 rAb Products

Our goal is to fast-track scientific advancements by delivering high-quality anti-PRKAB1 recombinant antibodies that merge strict quality control with outstanding cost-effectiveness and extensive professional support throughout your research journey.

Table 1. Featured anti-PRKAB1 recombinant antibody products at Creative Biolabs.

Creative Quality Control

To accelerate the progress of biopharmaceutical research, development, and commercialization, we firmly embrace a customer-focused philosophy that emphasizes meeting and surpassing the strictest quality demands of our clients. We have established a comprehensive quality management system designed to guarantee superior product standards, consistently aiming to go beyond customer expectations. Through delivering this exceptional value, our objective is to support partners in shortening drug development cycles and enhancing overall research productivity and effectiveness.

Customer Reviews

Excellent

Se**a
Mouse Anti-PRKAB1 Recombinant Antibody (ZG-0286F) (CAT#: ZG-0286F)

The Mouse Anti-PRKAB1 antibody works reliably in WB with clear detection of the ~30kDa band in HEK293T and HepG2 cell lysates. We observed some non-specific bands in mouse liver tissue samples that required optimization of blocking conditions. While it performs well for basic Western blotting applications, we haven't verified its suitability for IP or other techniques. For the price, it's a decent option if you primarily need WB validation of PRKAB1 expression.

19/Oct/2024

Excellent

E**en
Recombinant Rabbit Anti-PRKAB1 Monoclonal Antibody (CBACN-026) (CAT#: MRO-0091-CN)

The Recombinant Rabbit Anti-PRKAB1 works well for flow cytometry in fixed Jurkat and THP-1 cells, showing clean staining with low background. We've also tested it successfully in WB with HEK293T lysates. The antibody produces minimal non-specific binding in our hands, though optimal performance may require titration for different cell types. A reliable choice for basic PRKAB1 detection in suspension cells.

25/Jun/2024

Excellent

Ja**r
Mouse Anti-PRKAB1 Recombinant Antibody (clone 1A7-E11-E9) (CAT#: VS3-QX916)

Mouse Anti-PRKAB1 works decently for IP applications when using HEK293T cell lysates. We successfully pulled down the target with clean background, though the yield was moderate. Some optimization was needed for mouse liver tissue lysates. Haven't thoroughly tested cross-linking efficiency, but it's serviceable for basic co-IP studies if properly validated.

18/Dec/2023

rAb Production

Building on extensive experience in recombinant antibody design and refinement, we provide top-tier recombinant antibody products through efficient and simplified workflows that maintain the highest standards of quality and reliability, ensuring outstanding performance without sacrificing speed.

Featured Anti-PRKAB1 Recombinant Antibody Production Platforms
Fig.2 Milligram-scale recombinant antibody production.

Fig.3 Gram-scale recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to providing researchers with the most comprehensive and advanced high-quality recombinant antibodies across diverse formats. Our expertise in recombinant antibodies spans a broad array of engineering techniques, and our products are supported by exceptional custom engineering services designed to meet your specific requirements.

Fig.4 Full Length Anti-PRKAB1 Recombinant Antibody Production and Modalities.

For PRKAB1-related inquiries, our technical specialists are available to provide expert consultation. Researchers may contact us through standard channels for assistance with experimental optimization or troubleshooting needs. We're committed to supporting your investigation with tailored solutions throughout your research process.