Mouse Anti-PRKAB1 Recombinant Antibody (clone 5D8) (CAT#: VS3-WK1595)
This antibody is a mouse recombinant antibody against human PRKAB1, which may serve as an adaptor molecule mediating the association of the AMPK complex. The clone 5D8 can be used in IHC analysis at a dilution of 1/50-1/200.
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Subcellular Location and Protein Expression
RNA Expression
Figure 1 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4247/if_selected.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4247/if_selected.jpg
Figure 2 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000111725-PRKAB1/subcellular
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000111725-PRKAB1/subcellular
Specifications
- Immunogen
- Synthesized peptide derived from human AMPKβ1
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human PRKAB1
- Species Reactivity
- Human, Mouse, Rat
- Clone
- 5D8
- Applications
- IHC
- Conjugate
- Unconjugated
Product Property
- Clonality
- Monoclonal
- Purification
- Protein G affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Aggregation
- < 5%
- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS, 0.5% BSA, 50% Glycerol
- Preservative
- 0.02% Sodium Azide
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- IHC: 1/50-1/200
Target
- Alternative Names
- AMPK; HAMPKb
- Gene ID
- 5564
- UniProt ID
- Q9Y478
- Long Name
- Protein kinase AMP-activated non-catalytic subunit beta 1
- Sequence Similarities
- Belongs to the 5'-AMP-activated protein kinase beta subunit family.
- Cellular Localization
- Cytoplasm, Cytosol, Nucleoplasm, Nucleus
- Post Translation Modifications
- Phosphorylated when associated with the catalytic subunit (PRKAA1 or PRKAA2). Phosphorylated by ULK1; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1 and AMPK.
- Protein Refseq
- NP_006244.2
- Function
- Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Flow Cytometry (FC) related Reagents and Kits: Empowering Cell Function Research
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2846 | Hi-Affi™ Recombinant Rabbit Anti-PRKAB1 Monoclonal Antibody (DS2846AB) | WB, FC | IgG |
| MOR-4673 | Hi-Affi™ Recombinant Rabbit Anti-PRKAB1 Monoclonal Antibody (TH187DS) | WB, IF, ICC, IHC-P, FC | IgG |
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