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PSMA3
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2.
Protein class
Enzymes, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits (PubMed:25599644, 26133119, 26657688, 27342858, 27428775, 27493187, 34711951). The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings (PubMed:25599644, 26133119, 26657688, 27342858, 27428775, 27493187, 34711951). The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits (PubMed:25599644, 26133119, 26657688, 27342858, 27428775, 27493187, 34711951). The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7 (PubMed:25599644, 26133119, 26657688, 27342858, 27428775, 27493187, 34711951). Interacts with AURKB (PubMed:14674694). Interacts with CDKN1A (PubMed:11350925). Interacts with MDM2 and RB1 (PubMed:16337594). Interacts with the C-terminus of TBXA2R isoform 2 (PubMed:17499743). Interacts with DNAJB2 (PubMed:15936278). (Microbial infection) Interacts with HIV-1 Tat protein. (Microbial infection) Interacts with hepatitis C virus (HCV) F protein. (Microbial infection) Interacts with Epstein-Barr virus EBNA3 proteins.
More Types Infomation
- PE-A*02:01/Human PSMA3 (YMIDPSGVSY) MHC Tetramer (MHC-LC4321)
-
- Class: Class I
- Antigen: PSMA3
- Antigen Species: Human
- Peptide: YMIDPSGVSY
- Conjugate: PE
- PE-B*58:01/Human PSMA3 (YMIDPSGVSY) MHC Tetramer (MHC-LC4320)
-
- Class: Class I
- Antigen: PSMA3
- Antigen Species: Human
- Peptide: YMIDPSGVSY
- Conjugate: PE
- PE-A*29:02/Human PSMA3 (YMIDPSGVSY) MHC Tetramer (MHC-LC4319)
-
- Class: Class I
- Antigen: PSMA3
- Antigen Species: Human
- Peptide: YMIDPSGVSY
- Conjugate: PE
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: WB, IHC
-
- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, IHC, ICC, IP
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For Research Use Only. Not For Clinical Use.