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PTGS2
Anti-PTGS2 Recombinant Antibody Products
- Mouse Anti-PTGS2 Recombinant Antibody (VS-0224-XY104) (VS-0224-XY104)
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- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG1
- Application: ELISA, WB, IF, IP, IHC-P
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- Rabbit Anti-PTGS2 Recombinant Antibody (VS3-FY2608) (VS3-FY2608)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC
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For Research Use Only. Not For Clinical Use.
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis.
Protein class
Cancer-related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (granulocytes, Alveolar cells type 1, Langerhans cells, Fibroblasts, Macrophages, Urothelial cells)
Immune cell specificity
Immune cell enriched (neutrophil)
Cell line specificity
Cell line enriched (BJ hTERT+)
Interaction
Homodimer.
Molecular function
Dioxygenase, Oxidoreductase, Peroxidase
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Related Signaling Pathways
TNF Signaling Pathway