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PTGS2

Engineered Antibody
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis.
Protein class

Cancer-related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (granulocytes, Alveolar cells type 1, Langerhans cells, Fibroblasts, Macrophages, Urothelial cells)

Immune cell specificity

Immune cell enriched (neutrophil)

Cell line specificity

Cell line enriched (BJ hTERT+)

Interaction

Homodimer.

Molecular function

Dioxygenase, Oxidoreductase, Peroxidase

More Types Infomation
Related Signaling Pathways
TNF Signaling Pathway TNF Signaling Pathway

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