PTPN6
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Loading...- PE-B7/Human PTPN6 (VPSEPGGVL) MHC Tetramer (MHC-LC1966)
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- Class: Class I
- Antigen: PTPN6
- Antigen Species: Human
- Peptide: VPSEPGGVL
- Conjugate: PE
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- Recombinant Mouse Anti-PTPN6 Monoclonal Antibody (B5-A4) (MRO-1389-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG2b
- Application: WB, IF, IHC
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- Rabbit Anti-PTPN6 Polyclonal Antibody (MRO-2185-CN) (MRO-2185-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC
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- Rabbit Anti-PTPN6 Polyclonal Antibody (MRO-2186-CN) (MRO-2186-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IP, ELISA, ICC
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- Mouse Anti-PTPN6 Recombinant Antibody (HPAB-0535-FY) (HPAB-0535-FY)
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, ICC, IF, IHC, IP, FC
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- AbPlus™ Anti-PTPN6 Magnetic Beads (VS-0724-YC284) (VS-0724-YC284)
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- Target: PTPN6
- Target Species: Human
- Application: IP, Protein Purification
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- AbPlus™ Anti-Ptpn6 Magnetic Beads (VS-0724-YC1337) (VS-0724-YC1337)
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- Target: Ptpn6
- Target Species: Mouse
- Application: IP, Protein Purification
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- Mouse Anti-PTPN6 Recombinant Antibody; Fab Fragment (HPAB-0535-FY-F(E)) (HPAB-0535-FY-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
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- Mouse Anti-PTPN6 Recombinant Antibody; scFv Fragment (HPAB-0535-FY-S(P)) (HPAB-0535-FY-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: ICC, IF, WB, IHC-P, FC, IP
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- Mouse Anti-PTPN6 Recombinant Antibody (clone 2E9E4) (VS7-0425-WR721)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ICC, FC
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- Anti-PTPN6 Immunohistochemistry Kit (VS-0325-XY1824)
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- Species Reactivity: Human, Mouse, Rat
- Target: PTPN6
- Application: IHC
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- Anti-Mouse PTPN6 Immunohistochemistry Kit (VS-0525-XY5867)
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- Species Reactivity: Human, Mouse, Rat
- Target: PTPN6
- Application: IHC
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- Anti-Human PTPN6 Immunohistochemistry Kit (VS-0525-XY5866)
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- Species Reactivity: Human
- Target: PTPN6
- Application: IHC
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- Anti-PTPN6 Antibody Prodrug, Protease Activated (VS-1025-YC186) (VS-1025-YC186)
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- Species Reactivity: Human
- Host Animal: Mouse
- Target: PTPN6
- Application: ISZ, Cyt, FuncS
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For Research Use Only. Not For Clinical Use.
Background
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family.
Protein class
Enzymes, Metabolic proteins, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (B-cells, Hofbauer cells, NK-cells, Macrophages, Kupffer cells, granulocytes, Langerhans cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (HEL, HL-60, HMC-1, THP-1)
Interaction
Monomer. Interacts with MTUS1 (By similarity). Interacts with MILR1 (tyrosine-phosphorylated) (By similarity). Interacts with KIT (By similarity). Interacts with SIRPA/PTPNS1 (PubMed:9712903). Interacts with LILRB1 and LILRB2 (PubMed:9285411, 9842885). Interacts with LILRB4 (PubMed:9151699, 16493035). Interacts with FCRL2 and FCRL4 (PubMed:11162587, 14597715). Interacts with FCRL3 and FCRL6 (tyrosine phosphorylated form) (PubMed:20933011, 11162587, 19843936). Interacts with CD84 (PubMed:11414741). Interacts with CD300LF (PubMed:15184070). Interacts with CDK2 (PubMed:21262353). Interacts with KIR2DL1; the interaction is enhanced by ARRB2 (PubMed:18604210). Interacts (via SH2 1 domain) with ROS1; the interaction is direct and promotes ROS1 dephosphorylation (PubMed:11266449). Interacts with EGFR; inhibits EGFR-dependent activation of MAPK/ERK (PubMed:21258366). Interacts with LYN (PubMed:10574931). Interacts with the tyrosine phosphorylated form of PDPK1 (PubMed:19591923). Interacts with CEACAM1 (via cytoplasmic domain); this interaction depends on the monomer/dimer equilibrium and is phosphorylation-dependent (By similarity). Interacts with MPIG6B (via ITIM motif) (PubMed:23112346). Interacts with moesin/MSN. Interacts with CLEC12B (via ITIM motif).
Molecular function
Hydrolase, Protein phosphatase
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