Anti-ROR1 Recombinant Antibody Products

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Anti-ROR1 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs provides precision-engineered anti-ROR1 recombinant antibodies to support biomedical investigations across therapeutic and mechanistic studies. Leveraging proprietary antibody engineering technologies, these biologics demonstrate exceptional sensitivity and low cross-reactivity, validated through orthogonal experimental approaches. Their robust performance in applications spanning cellular phenotyping, signaling pathway analysis, and therapeutic target validation establishes them as critical tools for preclinical research.

ROR1: A Promising Target for Cancer Therapy

The receptor tyrosine kinase ROR1, a critical regulator of embryogenesis, exhibits marked overexpression across multiple malignancies. Experimental evidence indicates its oncogenic contributions occur through activation of survival signaling mechanisms, principally via non-canonical WNT5A-mediated cascades. Therapeutic antibodies targeting ROR1 have demonstrated preclinical efficacy and early clinical potential, positioning this receptor as an attractive therapeutic target in oncology.

Alternative Names

Tyrosine-protein kinase transmembrane receptor; receptor tyrosine kinase like orphan receptor 1; receptor tyrosine kinase-like orphan receptor 1; ROR1; NTRKR1; dJ537F10.1.

Background

This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms.

Anti-ROR1 rAb Products

Creative Biolabs develops functionally optimized recombinant antibodies targeting ROR1, designed to achieve high binding affinity and selective specificity. The modular configurations facilitate applications in immune system characterization, cancer biology research, and the screening of therapeutic candidates. Manufacturing processes incorporate structured quality assurance protocols, verified through complementary analytical techniques such as conformational epitope analysis and ligand-binding assays. Through the integration of structural optimization and standardized production protocols, these biologics demonstrate improved target selectivity, binding kinetics, and batch-to-batch consistency—thereby increasing reliability in both fundamental research and therapeutic development scenarios.

Table 1. Featured anti-ROR1 recombinant antibody products at Creative Biolabs.

Creative Quality Control

Creative Biolabs implements a multi-tiered quality control framework to develop recombinant antibodies targeting ROR1, achieving enhanced target specificity and favorable binding kinetics through iterative optimization processes. Systematic functional characterization of these biologics confirms reliable performance metrics across in vitro assays, ex vivo models, and preclinical studies, with batch-to-batch reproducibility validated through orthogonal analytical techniques. This methodological rigor positions the antibodies as critical reagents for molecular interrogation of ROR1-mediated signaling pathways in oncology and regenerative medicine research.

Customer Reviews

Excellent

Re***n
Human Anti-ROR1 Recombinant Antibody (HPAB-AP786-YC) (HPAB-AP786-YC)

The ROR1 antibody from Creative Biolabs showed excellent specificity in our flow cytometry experiments. We observed minimal off-target binding, which was crucial for our analysis.

21/May/2023

Excellent

Xi***u
Mouse Anti-ROR1 Recombinant Antibody (HPAB-673-FY) (HPAB-673-FY)

We were very satisfied with the consistency and performance of the ROR1 recombinant antibody. It worked well in our preclinical studies, providing reliable and reproducible data.

22/Sep/2024

Excellent

Da***n
Human Anti-ROR1 Recombinant Antibody (HPAB-0179-LSX) (CAT#: HPAB-0179-LSX)

Creative Biolabs offered a great selection of ROR1 antibodies. We found one that perfectly matched our research needs, and the technical support was very helpful throughout the ordering process.

13/Feb/2025

rAb Production

Creative Biolabs serves as a reliable global collaborator, providing a steady and trustworthy supply of high-quality anti-ROR1 recombinant antibodies to researchers across the globe. Utilizing advanced recombinant technology, our antibodies undergo thorough development and validation processes to ensure outstanding quality and effectiveness across various research applications. Our dedication lies in facilitating scientific advancement by equipping researchers with dependable tools essential for investigating the intricacies of ROR1 signaling across diverse biological scenarios.

Featured Anti-ROR1 Recombinant Antibody Production Platforms
Fig.7 Milligram-scale anti-ROR1 recombinant antibody production.

Fig.8 Gram-scale anti-ROR1 recombinant antibody production.

rAb Modalities

Creative Biolabs provides premium, customizable anti-ROR1 recombinant antibodies designed to address particular research requirements. These antibodies are available in multiple formats and are carefully designed to address the distinct requirements of research communities at local, national, and global levels.

Fig.9 Full-length anti-ROR1 recombinant antibody production and modalities.

ROR1-Targeted Drug Information

Table 2. Public drug targeting ROR1.

(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)

Leveraging our vast knowledge and years of remarkable experience in antibody creation and manufacturing, Creative Biolabs provides ROR1 recombinant antibodies that regularly show exceptional performance throughout a broad range of research uses. We are confident in the quality and reliability of our antibodies and encourage researchers interested in exploring the potential of ROR1 to get in touch with us directly to receive exclusive pricing details tailored to their specific needs.