Anti-ROR1 (R11) scFv-Fc-Sec ADC (CAT#: ADC-155LCT)

• Antibody Overview
• Mouse Anti-Human Monoclonal (R11) Antibody, scFv-FC

• Clone
• anti-ROR1 scFv-Fc, R11

• Linker
• engineered selenocysteine (Sec) residue

• Introduction
• This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012]

• Alternative Names
• ROR1; receptor tyrosine kinase-like orphan receptor 1; NTRKR1; dJ537F10.1; tyrosine-protein kinase transmembrane receptor ROR1; neurotrophic tyrosine kinase, receptor-related 1;

• Gene ID
• 4919

• UniProt ID
• Q01973

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