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RSPO2

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For Research Use Only. Not For Clinical Use.


Background

RSPO2 (R-Spondin 2) is a Protein Coding gene. Diseases associated with RSPO2 include Humerofemoral Hypoplasia With Radiotibial Ray Deficiency and Tetraamelia Syndrome 2. Among its related pathways are Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling and Signaling by Wnt. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and G protein-coupled receptor binding.
RSPO2
Protein class

Cancer-related genes, Disease related genes, Human disease related genes

Predicted location

Intracellular, Secreted (different isoforms)

Single cell type specificity

Group enriched (Inhibitory neurons, Excitatory neurons)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (HEK93, U-266/70)

Interaction

Interacts with WNT1 (By similarity). Binds heparin (By similarity). Interacts with LGR4, LGR5 and LGR6 (PubMed:21909076, PubMed:21727895, PubMed:22615920, PubMed:29769720). Interacts with E3 ubiquitin ligases RNF43 and ZNRF3 (PubMed:29769720).

Molecular function

Developmental protein, Heparin-binding

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