Mouse Anti-RSPO2 Recombinant Antibody (TAB-0226CL) (CAT#: TAB-0226CL)
The anti-RSPO2 antibody specifically binds human RSPO2 which synergizeds with Wnt to active beta-catin. The antibody can be used for the treatment study of pancreatic tumor, breast tumor and colorectal cancer.
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

(Immunohistochemical staining of human ovary shows strong positivity in follicle cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/24764/ihc_selected.jpg

(Immunohistochemical staining of human esophagus shows cytoplasmic positivity in squamous epithelial cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/53068/123521_B_4_1_selected.jpg

(Immunohistochemical staining of human liver shows strong cytoplasmic positivity in hepatocytes.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/25900/ihc_selected.jpg

(Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/24764/61238_A_8_8.jpg

(Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/24764/61238_A_9_5.jpg

(Decidual cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear Trophoblastic cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/25900/61111_A_2_7.jpg

(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000147655-RSPO2
Specifications
- Host Species
- Mouse
- Specificity
- Human
- Related Disease
- Pancreatic tumor, Breast Tumor, colorectal cancer
Target
Related Resources
Sami, Eman, et al. "The molecular underpinning of geminin-overexpressing triple-negative breast cancer cells homing specifically to lungs." Cancer gene therapy 29.3 (2022): 304-325. https://doi.org/10.1038/s41417-021-00311-x
This research investigates the molecular mechanisms underlying triple-negative breast cancer (TNBC) cells' ability to specifically metastasize to the lungs. Using differential/suppression subtractive chain (D/SSC) technique, the researchers identified a 24-gene signature induced by geminin overexpression (GemOE) that promotes lung-specific metastasis. Five key genes from this signature (LGR5, HAS2, CDH11, NCAM2, and DSC2) were associated with worsened lung metastasis-free survival in TNBC patients. The study demonstrates that LGR5-induced β-catenin signaling and stemness in TNBC cells are geminin-overexpression dependent. Additionally, the researchers discovered RSPO2 expression exclusively in mouse lung tissue and identified a novel extravasation receptor complex consisting of CDH11, CD44v6, c-Met, and AXL on GemOE/LGR5+ TNBC lung metastatic precursors.
Creative Biolabs provided three key neutralizing monoclonal antibodies: anti-CDH11 monoclonal antibody clone H14 (TAB-1413CL), anti-RSPO2 monoclonal antibody clone 130M23 (TAB-0226CL), and anti-CD44v6 monoclonal antibody clone BIWA 8 (HPAB-1173WJ). These antibodies were critical for in vivo neutralizing experiments that demonstrated blocking any component of the extravasation receptor complex prevented geminin overexpressing/LGR5+ TNBC lung metastasis. This contribution helped establish the therapeutic potential of targeting geminin in combination with components of the extravasation receptor complex to reduce TNBC lung metastasis and improve patient outcomes.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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See other products for "RSPO2"
Select a product category from the dropdown menu below to view related products.
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0232CL | Human Anti-RSPO2 Recombinant Antibody (TAB-0232CL) | ELISA, Inhib, Block, FuncS, In vivo | Humanized Antibody |
TAB-0232CL-S(P) | Human Anti-RSPO2 Recombinant Antibody scFv Fragment (TAB-0232CL-S(P)) | ELISA, Inhib, Block, FuncS, In vivo | Humanized Antibody |
TAB-0233CL-S(P) | Human Anti-RSPO2 Recombinant Antibody scFv Fragment (TAB-0233CL-S(P)) | ELISA, Inhib, Block, FuncS, In vivo | Humanized Antibody |
TAB-0232CL-F(E) | Human Anti-RSPO2 Recombinant Antibody Fab Fragment (TAB-0232CL-F(E)) | ELISA, Inhib, Block, FuncS, In vivo | Humanized Antibody |
TAB-0233CL-F(E) | Human Anti-RSPO2 Recombinant Antibody Fab Fragment (TAB-0233CL-F(E)) | ELISA, Inhib, Block, FuncS, In vivo | Humanized Antibody |
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For Research Use Only. Not For Clinical Use.
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